CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Multi-triggered and enzyme-mimicking graphene oxide/polyvinyl alcohol/G-quartet supramolecular hydrogels
Zhang, JX; Lu, N; Peng, HZ; Li, J; Yan, RH; Shi, XR; Ma, P; Lv, M; Wang, LH; Tang, ZS; Zhang, M
2020
Source PublicationNANOSCALE
ISSN2040-3364
Volume12Issue:8Pages:5186-5195
Subtype期刊论文
AbstractSupramolecular hydrogels with stimuli-responsive behaviors under aqueous environments are attractive for their potential applications in controlled drug delivery, clinical diagnostics, and tissue engineering. However, there still remain challenges in developing multicomponent hydrogels as a new generation of "smart" soft materials with multiple intelligent functions toward complex biochemical stimuli. In this work, a three dimensional (3D)-nanostructured supramolecular hydrogel was fabricated using a simple and facile strategy via the self-assembly of graphene oxide (GO) nanosheets, poly(vinyl alcohol) (PVA) chains, and G-quartet/hemin (G4/H) motifs. The as-prepared GO/PVA/G4/H hydrogel exhibited a honeycomb-like 3D GO network architecture as well as excellent mechanical properties. Importantly, the hydrogel demonstrated pH-inducing reversible and cyclic phase transitions between solution and hydrogel states, which could be used as "ink" for injectable 3D printing of different shaped patterns. Also, binary AND and OR logic gates were successfully built by encapsulating enzymes into the hydrogels, which responded to a variety of biochemicals. In addition, the hydrogels showed excellent peroxidase-like activity, achieving the ultrasensitive detection of H2O2 at a concentration as low as 100 nM by their deposition on an electrochemical electrode. The design of multicomponent hydrogels opens up an avenue to fabricate novel "smart" soft matter for biological and medical applications.
KeywordPEROXIDASE-LIKE ACTIVITY G-QUADRUPLEXES DNA PH NANOPARTICLES
DOI10.1039/c9nr10779g
Indexed BySCI ; EI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/33024
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Shanghai Univ Engn Sci, Sch Mat Engn, Shanghai 201620, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol, Shanghai 201800, Peoples R China
3.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai Synchrotron Radiat Facil, Shanghai 201210, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Endodont,Coll Stomatol, Shanghai 200011, Peoples R China
6.Natl Clin Res Ctr Oral Dis, Shanghai 200011, Peoples R China
7.Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China
8.Shanghai Res Inst Stomatol, Shanghai 200011, Peoples R China
9.Shanghai Univ Engn Sci, Coll Chem & Chem Engn, Shanghai 201620, Peoples R China
Recommended Citation
GB/T 7714
Zhang, JX,Lu, N,Peng, HZ,et al. Multi-triggered and enzyme-mimicking graphene oxide/polyvinyl alcohol/G-quartet supramolecular hydrogels[J]. NANOSCALE,2020,12(8):5186-5195.
APA Zhang, JX.,Lu, N.,Peng, HZ.,Li, J.,Yan, RH.,...&Zhang, M.(2020).Multi-triggered and enzyme-mimicking graphene oxide/polyvinyl alcohol/G-quartet supramolecular hydrogels.NANOSCALE,12(8),5186-5195.
MLA Zhang, JX,et al."Multi-triggered and enzyme-mimicking graphene oxide/polyvinyl alcohol/G-quartet supramolecular hydrogels".NANOSCALE 12.8(2020):5186-5195.
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