CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Peptides Co-Assembling into Hydrangea-Like Microstructures
Guo, Z; Shen, ZW; Wang, YJ; Tan, TY; Zhang, Y
2020
Source PublicationJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN1533-4880
Volume20Issue:5Pages:3239-3245
Subtype期刊论文
AbstractSupramolecular assembly in vitro is a simple and effective way to produce multi-level biostructures to mimic the self-assembly of biomolecules in organisms. The study on peptide assembly behaviors would benefit a lot to understand what goes on in life, as well as in the construction of plenty of functional biomaterials that have potential applications in various fields. Since cellular microenvironments are crowded and contain various biomolecules, studying protein and peptide co-assembly is of great interest. Here, we introduced the co-assembly of 5-FAM-ELVFFAE-NH2 (EE-7) and (CY5)-KLVFFAK-NH2 (KK-7), which are sequences derived from the core of the amyloid beta (A beta) peptide, a key protein in Alzheimer's diseases. Morphologic studies employing atomic force microscopy and scanning electron microscopy indicated that the co-assembled entities had a novel hydrangea-like microstructure, in contrast to micro-sheet structures formed from monocomponent EE-7 or KK-7, respectively. Fluorescence co-localization experiments confirmed that the hydrangea-like microstructures were indeed made of both EE-7 and KK-7. We suggest that the formation of the hydrangea-like microstructures is driven by both the electrostatic and hydrophobic interactions between EE-7 and KK-7. A molecular mechanism has been provided to explain the formation of the hydrangea-like microstructures.
KeywordPROTEIN SECONDARY STRUCTURE NEURODEGENERATIVE DISEASES AMYLOID HYPOTHESIS ALZHEIMERS-DISEASE DESIGN FIBERS SPECTROSCOPY AGGREGATION FIBRILS INSULIN
DOI10.1166/jnn.2020.17393
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/33059
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China
2.Chinese Acad Sci, Zhangjiang Lab, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Guo, Z,Shen, ZW,Wang, YJ,et al. Peptides Co-Assembling into Hydrangea-Like Microstructures[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2020,20(5):3239-3245.
APA Guo, Z,Shen, ZW,Wang, YJ,Tan, TY,&Zhang, Y.(2020).Peptides Co-Assembling into Hydrangea-Like Microstructures.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,20(5),3239-3245.
MLA Guo, Z,et al."Peptides Co-Assembling into Hydrangea-Like Microstructures".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 20.5(2020):3239-3245.
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