CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
PolyA-based DNA bonds with programmable bond length and bond energy
Chen, XL; Liu, XG; Yao, GB; Li, Q; Liu, RD; Wu, HJ; Lv, YN; Fan, CH; Wang, LH; Li, J
Source PublicationNPG ASIA MATERIALS
AbstractDNA-functionalized Au nanoparticles (AuNPs) have been intensively exploited as programmable atom equivalents (PAEs) for the self-assembly of molecule-like structures. However, it remains challenging to build hierarchical PAE assemblies via discrete DNA bonds at different levels. Here, we report a strategy to program DNA bond length and bond energy on PAEs using DNA encoders carrying consecutive adenines (polyA). On AuNPs, we built three types of DNA motifs with different topologic configurations, which can form bonds for PAE self-assembly. By small-angle X-ray scattering (SAXS) analysis, we found that the bond length and flexibility between the coupled PAEs can be tuned by programming the bond structure. We also found that these bonds show different bond energies and thus differ, depending on their topologic configuration, leading to different PAE assembly efficiencies. We demonstrated that the bonds at different levels can be arranged in different directions on one nanoparticle, leading to asymmetric PAEs that allow ionic strength-controlled hierarchical assembly of multiparticle structures. This programmable bonding system may provide a new route for building complex plasmonic superstructures.
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Affiliation1.Chinese Acad Sci, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai Inst Appl Phys,Univ Chinese Acad Sci, Shanghai 201800, Peoples R China
2.Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Inst Mol Med,Renji Hosp,Sch Med, Shanghai 200240, Peoples R China
3.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China
4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
Recommended Citation
GB/T 7714
Chen, XL,Liu, XG,Yao, GB,et al. PolyA-based DNA bonds with programmable bond length and bond energy[J]. NPG ASIA MATERIALS,2020,12(1):-.
APA Chen, XL.,Liu, XG.,Yao, GB.,Li, Q.,Liu, RD.,...&Li, J.(2020).PolyA-based DNA bonds with programmable bond length and bond energy.NPG ASIA MATERIALS,12(1),-.
MLA Chen, XL,et al."PolyA-based DNA bonds with programmable bond length and bond energy".NPG ASIA MATERIALS 12.1(2020):-.
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