CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone
Dai, Y; Guo, H; Chu, LY; He, ZH; Wang, MQ; Zhang, SH; Shang, XF
2020
Source PublicationJOURNAL OF ORTHOPAEDIC TRANSLATION
ISSN2214-031X
Volume24Pages:198-208
Subtype期刊论文
AbstractObjective: To enhance the bioactivity of polyetheretherketone (PEEK) while maintain its mechanical strengths. Methods: Suspension coating and melt bonding. Results: Silicon nitride (Si3N4, SN) coating lead to higher surface roughness, hydrophilicity and protein absorption; SN coating could slowly release Si ion into simulated body fluid (SBF), which caused weak alkaline of micro-environment owing to the slight dissolution of SN; SN coating resulted in the improvements of adhesion, proliferation, differentiation and gene expressions of MC3T3-E1 cells in vitro; SN coating of PEEK with bioactive SN coating (CSNPK) obviously promoted bone regeneration and osseointegration in vivo. Conclusions: CSNPK with SN coating as bone implant might be a promising candidate for orthopedic implants. The Translational Potential of this Article: The silicon nitride-coated polyetheretherketone (CSNPK) prepared in this article could induce MC3T3-E1 cells adhesion, proliferation and differentiation in vitro; it could also induce bone regeneration in bone defect in vivo, which indicate its good cytocompatibility and biocompatibility. If the raw materials are medical grade, and preparation process as well as production process of this article are further improved, it will have great translational potential.
KeywordSTRUCTURAL ORTHOPEDIC IMPLANTS SILICON-NITRIDE OSSEOINTEGRATION PROLIFERATION DIFFERENTIATION MICROSTRUCTURE COMPOSITE SCAFFOLD CELLS
DOI10.1016/j.jot.2019.10.011
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/33093
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Shandong Univ, Jinan 250012, Shandong, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Sch Med,Shanghai Key Lab Orthopaed Implants, Shanghai 200011, Peoples R China
4.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Orthopaed Surg, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China
5.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, 239 Zhangheng Rd, Shanghai 201204, Peoples R China
Recommended Citation
GB/T 7714
Dai, Y,Guo, H,Chu, LY,et al. Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2020,24:198-208.
APA Dai, Y.,Guo, H.,Chu, LY.,He, ZH.,Wang, MQ.,...&Shang, XF.(2020).Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone.JOURNAL OF ORTHOPAEDIC TRANSLATION,24,198-208.
MLA Dai, Y,et al."Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone".JOURNAL OF ORTHOPAEDIC TRANSLATION 24(2020):198-208.
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