CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes
Shen, ZW; Guo, Z; Tan, TY; Hu, J; Zhang, Y
2020
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
ISSN2373-9878
Volume6Issue:7Pages:3957-3966
Subtype期刊论文
AbstractMyocardial ischemia-reperfusion produces a large amount of reactive oxygen species (ROS), which damage the myocardial tissue. Therefore, localized scavenging of ROS from the myocardial tissue would reduce its damage and avoid metabolic abnormalities caused by systemic ROS. In this study, a free radical scavenging and biodegradable supramolecular peptide (ECAFF, named as ECF-5) hydrogel was designed as a culture scaffold for cardiomyocytes. The peptide hydrogel significantly preserved the migration and proliferation of cardiomyocytes and reduced their damage from oxidative stress. In addition, the hydrogel degraded during cell growth, which implies that it may avoid thrombosis of the capillaries in practical use and provide the opportunity for the cells to attach to each other and form a functional tissue. The hydrogel can be used as a 3D culture scaffold for cardiomyocyte culture and allow cardiomyocytes to grow into tissue-like cell spheres. The excellent nature of the ECF-5 hydrogel enables it to have broad applications in the biomedical field in the future.
KeywordOXIDATIVE STRESS DAMAGE STEM-CELLS SUPPRESSION THERAPY ALPHA
DOI10.1021/acsbiomaterials.0c00340
Indexed BySCI ; EI
Language英语
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Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/33105
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China
2.Chinese Acad Sci, Zhangjiang Lab, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Shen, ZW,Guo, Z,Tan, TY,et al. Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(7):3957-3966.
APA Shen, ZW,Guo, Z,Tan, TY,Hu, J,&Zhang, Y.(2020).Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(7),3957-3966.
MLA Shen, ZW,et al."Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.7(2020):3957-3966.
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