CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Sensitive imagine of intact microvessels in vivo with synchrotron radiation
Wang, FX; Zhou, PT; Li, K; Mamtilahun, M; Tang, YH; Du, GH; Deng, B; Xie, HL; Yang, GY; Xiao, TQ
2020
Source PublicationIUCRJ
ISSN2052-2525
Volume7Pages:793-802
Subtype期刊论文
AbstractEarly stages of diseases, including stroke, hypertension, angiogenesis of tumours, spinal cord injuries, etc., are closely associated with the lesions of microvasculature. Rodent models of human vascular diseases are extensively used for the preclinical investigation of the disease evolution and therapy with synchrotron radiation. Therefore, non-invasive and in vivo X-ray imaging with high sensitivity and clarity is desperately needed to visualize the microvessels in live-animal models. Contrast agent is essential for the in vivo X-ray imaging of vessels and angiomatous tissue. Because of the non-rigid motion of adjacent tissues, the short circulation time and the intermittent flow of contrast agents in vessels, it is a great challenge for the traditional X-ray imaging methods to achieve well defined images of microvessels in vivo. In this article, move contrast X-ray imaging (MCXI) based on high-brightness synchrotron radiation is developed to overcome the intrinsic defects in conventional methods. Experiments with live rodents demonstrate the practicability of the MCXI method for sensitive and intact imaging of microvessels in vivo.
KeywordCOMPUTED-TOMOGRAPHY DRUG-DELIVERY ANGIOGRAPHY NANOPARTICLES CANCER BRAIN
DOI10.1107/S2052252520008234
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/33130
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, Zhangjiang Lab, Shanghai 201204, Peoples R China
2.Shanghai Jiao Tong Univ, Neurosci & Neuroengn Res Ctr, Med X Res Inst, Shanghai 200030, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, FX,Zhou, PT,Li, K,et al. Sensitive imagine of intact microvessels in vivo with synchrotron radiation[J]. IUCRJ,2020,7:793-802.
APA Wang, FX.,Zhou, PT.,Li, K.,Mamtilahun, M.,Tang, YH.,...&Xiao, TQ.(2020).Sensitive imagine of intact microvessels in vivo with synchrotron radiation.IUCRJ,7,793-802.
MLA Wang, FX,et al."Sensitive imagine of intact microvessels in vivo with synchrotron radiation".IUCRJ 7(2020):793-802.
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