CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Single cell imaging with near-field terahertz scanning microscopy
Li, ZX; Yan, SH; Zang, ZY; Geng, GS; Yang, ZB; Li, J; Wang, LH; Yao, CY; Cui, HL; Chang, C; Wang, HB
2020
Source PublicationCELL PROLIFERATION
ISSN0960-7722
Volume53Issue:4Pages:-
Subtype期刊论文
AbstractObjectives Terahertz (THz)-based imaging techniques hold great potential for biological and biomedical applications, which nevertheless are hampered by the low spatial resolution of conventional THz imaging systems. In this work, we report a high-performance photoconductive antenna microprobe-based near-field THz time-domain spectroscopy scanning microscope. Materials and methods A single watermelon pulp cell was prepared on a clean quartz slide and covered by a thin polyethylene film. The high performance near-field THz microscope was developed based on a coherent THz time-domain spectroscopy system coupled with a photoconductive antenna microprobe. The sample was imaged in transmission mode. Results We demonstrate the direct imaging of the morphology of single watermelon pulp cells in the natural dehydration process with our near-field THz microscope. Conclusions Given the label-free and non-destructive nature of THz detection techniques, our near-field microscopy-based single-cell imaging approach sheds new light on studying biological samples with THz.
KeywordTIME SPECTROSCOPY DYNAMICS INSIGHTS GROWTH WATER
DOI10.1111/cpr.12788
Indexed BySCI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/33137
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Chinese Acad Sci, Ctr Appl Phys, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China
2.Chinese Acad Sci, Chongqing Engn Res Ctr High Resolut & Three Dimen, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China
3.Jilin Univ, Coll Instrumentat & Elect Engn, Changchun, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai, Peoples R China
5.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai Synchrotron Radiat Facil,Bioimaging Ctr, Shanghai, Peoples R China
6.Third Mil Med Univ, Southwest Hosp, Dept Transfus Med, Army Med Univ, Chongqing 400038, Peoples R China
7.Tsinghua Univ, Dept Engn Phys, Beijing, Peoples R China
8.Natl Innovat Inst Def Technol, Adv Interdisciplinary Technol Res Ctr, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Li, ZX,Yan, SH,Zang, ZY,et al. Single cell imaging with near-field terahertz scanning microscopy[J]. CELL PROLIFERATION,2020,53(4):-.
APA Li, ZX.,Yan, SH.,Zang, ZY.,Geng, GS.,Yang, ZB.,...&Wang, HB.(2020).Single cell imaging with near-field terahertz scanning microscopy.CELL PROLIFERATION,53(4),-.
MLA Li, ZX,et al."Single cell imaging with near-field terahertz scanning microscopy".CELL PROLIFERATION 53.4(2020):-.
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