CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy
Wang, YD; Wang, Y; Qian, J; Pan, XH; Li, XL; Chen, F; Hu, J; Lu, JH
2020
Source PublicationCHEMICAL COMMUNICATIONS
ISSN1359-7345
Volume56Issue:86Pages:13237-13240
Subtype期刊论文
AbstractWe conceptually demonstrate single-cell infrared phenomics as a novel strategy of phenotypic screening with infrared microspectroscopy. Based on this development, the cancer cell HepG2 glycocalyx was first identified as a potential target of protopanaxadiol, an herbal medicine. These findings provide a powerful tool to accurately evaluate the cell stress response and to largely expand the phenotypic screening toolkit for drug discovery.
KeywordDRUG DISCOVERY SYSTEMS
DOI10.1039/d0cc05721e
Indexed BySCI ; EI
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/33140
Collection中科院上海应用物理研究所2011-2020年
Affiliation1.Binzhou Med Univ, Coll Pharm, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai Synchrotron Radiat Facil, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Shanghai Univ Med & Hlth Sci, Natl Engn Res Ctr Nanotechnol, Shanghai 201318, Peoples R China
6.Capital Med Univ, Beijing Tiantan Hosp, Beijing 100070, Peoples R China
Recommended Citation
GB/T 7714
Wang, YD,Wang, Y,Qian, J,et al. Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy[J]. CHEMICAL COMMUNICATIONS,2020,56(86):13237-13240.
APA Wang, YD.,Wang, Y.,Qian, J.,Pan, XH.,Li, XL.,...&Lu, JH.(2020).Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy.CHEMICAL COMMUNICATIONS,56(86),13237-13240.
MLA Wang, YD,et al."Single-cell infrared phenomics: phenotypic screening with infrared microspectroscopy".CHEMICAL COMMUNICATIONS 56.86(2020):13237-13240.
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