CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Aqueous immune magnetite nanoparticles for immunoassay
Zhang, GX(张国欣); Liu, YB; Zhang, CF(张春富); Hu, WQ; Xu, WB; Li, Z; Liang, S; Cao, JQ(曹金全); Wang, YX(汪勇先); Wang, YX (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2009
Source PublicationJOURNAL OF NANOPARTICLE RESEARCH
ISSN1388-0764
Volume11Issue:2Pages:8
AbstractImmune magnetite nanoparticles (MNPs) are prepared by four successive reactions, which are MNPs preparation, silica-coating, surface modification with amino group, and conjugation with bio-molecule, respectively. The crystal structure and morphology of intermediate products are characterized by XRD, TEM and AFM. Qualitative and quantitative assays for amino group on the MNPs' surface are made by FTIR and Organic Element Assay. Ultraviolet-visible absorption spectrum can indirectly illustrate the quantity of bio-molecule conjugated with MNPs. In addition, specific combination and nonspecific combination of immune MNPs are measured by commercial RIA box. The results show that the size of MNPs prepared is 10 +/- A 5 nm, and silica-coated MNPs with spinel structure have quasi-spherical morphology. Infrared absorption bands of -NH(2) are appeared around 3380-3200 cm(-1) and 1650-1510 cm(-1), and the amino group content is 0.5 mu mol -NH(2) per mg MNPs. The specific immune combination of immune MNPs is up to 75%, and nonspecific combination is under 5%.
KeywordMagnetite Nanoparticles Silica-coating Surface Modification Immunity Nanomedicine
Subject AreaChemistry ; Science & Technology - Other Topics ; Materials Science
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000262987800018
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/6842
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorWang, YX (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Zhang, GX,Liu, YB,Zhang, CF,et al. Aqueous immune magnetite nanoparticles for immunoassay[J]. JOURNAL OF NANOPARTICLE RESEARCH,2009,11(2):8.
APA Zhang, GX.,Liu, YB.,Zhang, CF.,Hu, WQ.,Xu, WB.,...&Wang, YX .(2009).Aqueous immune magnetite nanoparticles for immunoassay.JOURNAL OF NANOPARTICLE RESEARCH,11(2),8.
MLA Zhang, GX,et al."Aqueous immune magnetite nanoparticles for immunoassay".JOURNAL OF NANOPARTICLE RESEARCH 11.2(2009):8.
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