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| Photo and pH Stable, Highly-Luminescent Silicon Nanospheres and Their Bioconjugates for Immunofluorescent Cell Imaging | |
| He, Y; Su, YY; Yang, XB; Kang, ZH; Xu, TT; Zhang, RQ; Fan, CH(樊春海）; Lee, ST; Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China | |
| 2009 | |
| Source Publication | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| ISSN | 0002-7863 |
| Volume | 131Issue:12Pages:5 |
| Abstract | We report a novel kind of oxidized silicon nanospheres (O-SiNSs), which simultaneously possess excellent aqueous dispersibility, high photoluminescent quantum yield (PLQY), ultra photostability, wide pH stability, and favorable biocompatibility. Significantly, the PLQY of the O-SiNSs is as high as 25%, and is stable under intense UV irradiation and in acidic-to-basic environments covering the pH range 2-12. To our best knowledge, it is the first example of water-dispersed silicon nanoparticles which possess both high PLQY and robust pH stability suitable for broad utility in bioapplications. Furthermore, the O-SiNSs are readily conjugated with antibody, and the resultant O-SiNSs/antibody bioconjugates are successfully applied in immunofluorescent cell imaging. The results show that the highly luminescent and stable O-SiNSs/antibody bioconjugates are promising fluorescent probes for wide-ranging bioapplications, such as long-term and real-time cellular labeling. |
| Subject Area | Chemistry |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000264792900054 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/7007 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Corresponding Author | Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| Recommended Citation GB/T 7714 | He, Y,Su, YY,Yang, XB,et al. Photo and pH Stable, Highly-Luminescent Silicon Nanospheres and Their Bioconjugates for Immunofluorescent Cell Imaging[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2009,131(12):5. |
| APA | He, Y.,Su, YY.,Yang, XB.,Kang, ZH.,Xu, TT.,...&Fan, CH .(2009).Photo and pH Stable, Highly-Luminescent Silicon Nanospheres and Their Bioconjugates for Immunofluorescent Cell Imaging.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,131(12),5. |
| MLA | He, Y,et al."Photo and pH Stable, Highly-Luminescent Silicon Nanospheres and Their Bioconjugates for Immunofluorescent Cell Imaging".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131.12(2009):5. |
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