CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Toxicological study of injuries of rat's hippocampus after lead poisoning by synchrotron microradiography and elemental mapping
Liang, F; Zhang, GL; Xiao, XH; Cai, ZH; Lai, B; Hwu, Y; Yan, CH; Xu, JA; Li, YL; Tan, MG; Zhang, CF; Li, Y; Zhang, GL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2010
Source PublicationNUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
ISSN0168-583X
Volume268Issue:17-18Pages:6
AbstractThe hippocampus, a major component of the brain, is one of the target nervous organs in lead poisoning In this work, a rat's hippocampal injury caused by lead was studied. The lead concentrations in blood, bone and hippocampus collected from rats subject to lead poisoning were quantified by Inductively Coupled Plasma Mass Spectrometry while morphological information and elemental distributions in the hippocampus were obtained with synchrotron radiation X-ray phase contrast imaging and synchrotron radiation micro-beam X-ray fluorescence, respectively For comparison, identical characterization of the specimens from the rats in the control group was done in parallel Results show that the ratios between the lead content in the treated group and that in the control group of the hippocampus, bone, and blood are about 2 66, 236, and 39 6, respectively Analysis also revealed that some health elements such as S. K. Cl and P increase in the regions with high lead content in the treated hippocampus Morphological differences between the normal and lead-exposed hippocampus specimens in some local areas were observed. Explicitly, the structure of the lead-exposed hippocampus was tortuous and irregular, and the density of the neurons in the Dentate Gyrus was significantly lower than that from the control group The study shows that the synchrotron radiation methods are very powerful for investigating structural injury caused by heavy metals in the nervous system. (C) 2010 Elsevier B V All rights reserved
KeywordHippocampus Lead Phase Contrast X-ray Imaging Micro-beam X-ray Fluorescence Synchrotron Radiation
Subject AreaInstruments & Instrumentation ; Nuclear Science & Technology ; Physics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000281498900047
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7099
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorZhang, GL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Liang, F,Zhang, GL,Xiao, XH,et al. Toxicological study of injuries of rat's hippocampus after lead poisoning by synchrotron microradiography and elemental mapping[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,2010,268(17-18):6.
APA Liang, F.,Zhang, GL.,Xiao, XH.,Cai, ZH.,Lai, B.,...&Zhang, GL .(2010).Toxicological study of injuries of rat's hippocampus after lead poisoning by synchrotron microradiography and elemental mapping.NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,268(17-18),6.
MLA Liang, F,et al."Toxicological study of injuries of rat's hippocampus after lead poisoning by synchrotron microradiography and elemental mapping".NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 268.17-18(2010):6.
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