CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Application of X-ray Phase Contrast Imaging Technique in Detection of Pulmonary Lesions Induced by Multi-Walled Carbon Nanotubes in Rats
Li, JG; Xue, YL(薛艳玲); Han, B; Li, QN(李晴暖); Liu, LX; Xiao, TQ(肖体乔); Li, WX(李文新); Xiao, TQ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2008
Source PublicationJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN1533-4880
Volume8Issue:7Pages:3357
AbstractWith X-ray phase contrast imaging technique, the pulmonary lesions induced by multi-walled carbon nanotubes were preliminarily studied in this work. After 0.1, 1 and 2 mg nanotubes were delivered into lungs of rats via trachea, their acute pulmonary toxicity (at 5-day postexposure) was assessed using X-ray phase contrast, absorption contrast imaging and routine pathological slice techniques. As such, the long-term pulmonary toxicity (at 140-day postexposure), induced by single intratracheal instillation of 0.1 mg nanotubes, was assessed using X-ray phase contrast imaging and pathological slice techniques. As a consequence, the nanotubes could induce obvious density and structural integrity alternation in lung tissue at 5-day postexposure and granulomas at 140-day postexposure, and these pathologic lesions could be efficiently detected out with the phase imaging technique. By comparison, this technique not only gained advantage over the conventional X-ray absorption contrast imaging but also could supply the gap of routine pathological slice in detecting pulmonary lesions induced by carbon nanotubes. It is hoped that this work can act as an impetus for further application of phase imaging technique to nanotoxicology and to assessment of occupational safety of nanomaterials.
Subject AreaScience & Technology - Other Topics ; Materials Science ; Physics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000260776600008
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7655
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorXiao, TQ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Li, JG,Xue, YL,Han, B,et al. Application of X-ray Phase Contrast Imaging Technique in Detection of Pulmonary Lesions Induced by Multi-Walled Carbon Nanotubes in Rats[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2008,8(7):3357.
APA Li, JG.,Xue, YL.,Han, B.,Li, QN.,Liu, LX.,...&Xiao, TQ .(2008).Application of X-ray Phase Contrast Imaging Technique in Detection of Pulmonary Lesions Induced by Multi-Walled Carbon Nanotubes in Rats.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,8(7),3357.
MLA Li, JG,et al."Application of X-ray Phase Contrast Imaging Technique in Detection of Pulmonary Lesions Induced by Multi-Walled Carbon Nanotubes in Rats".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 8.7(2008):3357.
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