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Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation
Xu, JY; Li, QN(李晴暖); Li, JG; Ran, TC; Wu, SW(吴胜伟); Song, WM; Chen, SL; Li, WX(李文新); Li, WX (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2007
Source PublicationCARBON
ISSN0008-6223
Volume45Issue:9Pages:1865
AbstractAn increasing number of studies have been devoted to studying the respiratory toxicity of carbon nanomaterials, but little information is known, thus far, on the biodistribution of these nanomaterials after inhalation or intratracheal instillation. We synthesized and labeled a polyhydroxylated derivative of fullerene C-60(OH)(x) (x = 22,24) with Tc-99m. With single photon emission computed tomography imaging and (gamma)-ray counting techniques, the biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation was studied. It was found that, besides the highest retention in the lung, Tc-99m-C-67(OH)(x) is distributed mainly in the liver, bone, and spleen, with no uptake found in brain. The long-term retention in the lung and the very fast clearance from the blood revealed a transient characteristic of penetrating the alveolar-capillary barrier. The dimensions and size distribution, as well as in vivo aggregation of 99mTc-C60(OH)(x),, may affect the capability and kinetic process of penetrating the alveolar-capillary barrier. The results provide guidance for further study of the respiratory toxicity of carbon nanornaterials. (c) 2007 Elsevier Ltd. All rights reserved.
Subject AreaPhysics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000248935500018
Citation statistics
Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7664
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorLi, WX (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Xu, JY,Li, QN,Li, JG,et al. Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation[J]. CARBON,2007,45(9):1865.
APA Xu, JY.,Li, QN.,Li, JG.,Ran, TC.,Wu, SW.,...&Li, WX .(2007).Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation.CARBON,45(9),1865.
MLA Xu, JY,et al."Biodistribution of Tc-99m-C-60(OH)(x) in Sprague-Dawley rats after intratracheal instillation".CARBON 45.9(2007):1865.
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