CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Blood lead: Its effect on trace element levels and iron structure in hemoglobin
Jin, C; Li, Y; Li, YL; Zou, Y; Zhang, GL; Normura, M; Zhu, GY; Li, Y (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2008
Source PublicationNUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
ISSN0168-583X
Volume266Issue:16Pages:3607
AbstractLead is a ubiquitous environmental pollutant that induce a broad range of physiological and biochemical dysfunctions. The purpose of this study was to investigate its effects on trace elements and the iron structure in hemoglobin. Blood samples were collected from rats that had been exposed to lead. The concentration of trace elements in whole blood and blood plasma was determined by ICP-MS and the results indicate that lead exists mainly in the red blood cells and only about 1-3% in the blood plasma. Following lead exposure, the concentrations of zinc and iron in blood decrease, as does the hemoglobin level. This indicates that the heme biosynthetic pathway is inhibited by lead toxicity and that lead poisoning-associated anemia occurs. The selenium concentration also decreases after lead exposure, which may lead to an increased rate of free radical production. The effect of lead in the blood on iron structure in hemoglobin was determined by EXAFS. After lead exposure, the Fe-O bond length increases by about 0.07 angstrom and the Fe-Np bond length slightly increases, but the Fe-N-epsilon bond length remains unchanged. This indicates that the blood content of Hb increases, but that the content of HbO(2) decreases. (C) 2008 Elsevier B.V. All rights reserved.
Subject AreaChemistry
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000259429100015
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7665
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorLi, Y (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Jin, C,Li, Y,Li, YL,et al. Blood lead: Its effect on trace element levels and iron structure in hemoglobin[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,2008,266(16):3607.
APA Jin, C.,Li, Y.,Li, YL.,Zou, Y.,Zhang, GL.,...&Li, Y .(2008).Blood lead: Its effect on trace element levels and iron structure in hemoglobin.NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS,266(16),3607.
MLA Jin, C,et al."Blood lead: Its effect on trace element levels and iron structure in hemoglobin".NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS 266.16(2008):3607.
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