CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation
Li, JG; Li, WX(李文新); Xu, JY; Cai, XQ; Liu, RL(刘瑞丽); Li, YJ(李永军); Zhao, QF; Li, QN(李晴暖); Li, QN (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2007
Source PublicationENVIRONMENTAL TOXICOLOGY
ISSN1520-4081
Volume22Issue:4Pages:415
AbstractThe pathological lesions induced by multiwalled carbon nanotubes (MWCNTs) in bronchi and alveoli of mice were studied by intratracheal instillation and inhalation. In instillation groups, the dose was 0.05 mg MWCNTs/mouse. Similar size clumps of MWCNTs were distributed in bronchi and alveoli. The clumps led to inflammation to the lining wall of bronchi and severe destruction to alveolar netted structure around them. In the inhalation groups, the mice were exposed to aerosolized MWCNTs with mean concentration of 32.61 mg/m(3), the intralung deposition dose were roughly 0.07, 0.14, and 0.21 mg in the 8-day group, 16-day group, and 24-day group, respectively. Most of aggregations of MWCNTs in the alveoli were smaller than that in bronchi. The aggregations induced proliferation and thickening of alveolar walls. With the exception of these moderate pathological lesions, the general alveolar structure was still remained. The preliminary study demonstrated a difference in lung pathological lesions induced by instilled MWCNTs and inhaled ones, which may be due to the different size and distribution of aggregations of MWCNTs in lung. (C) 2007 Wiley Periodicals, Inc. Environ Toxicol 22: 415-421, 2007.
Subject AreaChemistry
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000248189800009
Citation statistics
Cited Times:129[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7675
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorLi, QN (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Li, JG,Li, WX,Xu, JY,et al. Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation[J]. ENVIRONMENTAL TOXICOLOGY,2007,22(4):415.
APA Li, JG.,Li, WX.,Xu, JY.,Cai, XQ.,Liu, RL.,...&Li, QN .(2007).Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation.ENVIRONMENTAL TOXICOLOGY,22(4),415.
MLA Li, JG,et al."Comparative study of pathological lesions induced by multiwalled carbon nanotubes in lungs of mice by intratracheal instillation and inhalation".ENVIRONMENTAL TOXICOLOGY 22.4(2007):415.
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