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Comparative study on the acute pulmonary toxicity induced by 3 and 20 nm TiO2 primary particles in mice
Li, JA; Li, QN(李晴暖); Xu, JY; Li, J; Cai, XQ; Liu, RL; Li, YJ; Ma, JF; Li, WX(李文新); Li, QN (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2007
Source PublicationENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
Volume24Issue:3Pages:239
AbstractThe acute pulmonary toxicity induced by 3-nm TiO2 primary particles was preliminary investigated after they were intratracheally instilled at doses of 0.4,4 and 40 mg/kg into lungs of mice. The biochemical parameters in bronchoalveolar lavage fluid (BALF) and pathological examination were used as endpoints to assess their pulmonary toxicity at 3-day postexposure. As such, the pulmonary toxicity assessment of 20-nm TiO2 primary particles was performed using the same method. It was found that the 3-nm TiO2 primary particles induced no pulmonary toxicity at dose of 0.4 mg/kg, moderate toxicity at 4 mg/kg and lung overload at 40 mg/kg, and this kind of particles did not produce more pulmonary toxicity than the 20-nm ones at any instilled doses. As regards physicochemical characteristics of the two TiO2 particles, their pH values in medium, other than particle size, surface area and aggregation, may play important role in affecting their pulmonary toxicity. (C) 2007 Elsevier B.V. All rights reserved.
Subject AreaChemistry ; Nuclear Science & Technology ; Physics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000250697200007
Citation statistics
Cited Times:47[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7676
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorLi, QN (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Li, JA,Li, QN,Xu, JY,et al. Comparative study on the acute pulmonary toxicity induced by 3 and 20 nm TiO2 primary particles in mice[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2007,24(3):239.
APA Li, JA.,Li, QN.,Xu, JY.,Li, J.,Cai, XQ.,...&Li, QN .(2007).Comparative study on the acute pulmonary toxicity induced by 3 and 20 nm TiO2 primary particles in mice.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,24(3),239.
MLA Li, JA,et al."Comparative study on the acute pulmonary toxicity induced by 3 and 20 nm TiO2 primary particles in mice".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 24.3(2007):239.
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