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| Design and synthesis of delivery system based on SBA-15 with magnetic particles formed in situ and thermo-sensitive PNIPA as controlled switch | |
| Zhu, SM; Zhou, ZY; Zhang, D; Jin(金婵）, C; Li, ZQ; Zhang, D (reprint author), Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, 1954 Huashan Rd, Shanghai 200030, Peoples R China | |
| 2007 | |
| Source Publication | MICROPOROUS AND MESOPOROUS MATERIALS
 |
| ISSN | 1387-1811 |
| Volume | 106Issue:40546Pages:56 |
| Abstract | A novel responsive carrier system based on ordered mesoporous silica SBA-15 was synthesized, with magnetic particles formed in situ and thermo-sensitive poly(N-isopropyl acrylamide) (PNIPA) polymerized inside the pores. It was interesting to find that the obtained system held a relatively large pore diameter (3.8 nm) and pore volume (0.47 cm(3) g(-1)), which would benefit for drug storage with relatively large molecules. The delivery system displayed a hysteresis loop with a saturation magnetization (M-s) of 0.40 emu/g, which revealed the magnetic property of the prepared system. In vitro test of ibuprofen (IBU) loading and release exhibited a pronounced transition at around 17 degrees C, indicating a typical thermo-sensitive release property for this delivery system. (c) 2007 Elsevier Inc. All rights reserved. |
| Subject Area | Spectroscopy |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/7685 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Corresponding Author | Zhang, D (reprint author), Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, 1954 Huashan Rd, Shanghai 200030, Peoples R China |
| Recommended Citation GB/T 7714 | Zhu, SM,Zhou, ZY,Zhang, D,et al. Design and synthesis of delivery system based on SBA-15 with magnetic particles formed in situ and thermo-sensitive PNIPA as controlled switch[J]. MICROPOROUS AND MESOPOROUS MATERIALS,2007,106(40546):56. |
| APA | Zhu, SM,Zhou, ZY,Zhang, D,Jin,Li, ZQ,&Zhang, D .(2007).Design and synthesis of delivery system based on SBA-15 with magnetic particles formed in situ and thermo-sensitive PNIPA as controlled switch.MICROPOROUS AND MESOPOROUS MATERIALS,106(40546),56. |
| MLA | Zhu, SM,et al."Design and synthesis of delivery system based on SBA-15 with magnetic particles formed in situ and thermo-sensitive PNIPA as controlled switch".MICROPOROUS AND MESOPOROUS MATERIALS 106.40546(2007):56. |
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