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Fast repair of oxidative DNA damage by phenylpropanoid glycosides and their analogues
Shi, YM; Wang, WF(王文锋); Huang, CY; Jia, ZJ; Yao, SD(姚思德); Zheng, RL; Zheng, RL (reprint author), Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China
2008
Source PublicationMUTAGENESIS
ISSN0267-8357
Volume23Issue:1Pages:19
AbstractThe repair activities and reaction mechanisms of phenylpropanoid glycosides (PPGs) and their analogues, isolated from Chinese folk medicinal herbs, towards oxidative DNA damage were studied with pulse radiolytic technique. On pulse irradiation of nitrogen-saturated 4 mM poly C aqueous solution containing one of the tested polyphenols, 40 mM K2S2O8 and 200 mM t-BuOH, the transient absorption spectrum of the oxidative radical of poly C decays with the concurrent formation of the phenoxyl radical of the tested polyphenols within several tens of microseconds after the electron pulse irradiation. The result indicated that there was a repair reaction between oxidative radical of poly C and the tested polyphenols. The repair activities also were observed for the tested polyphenols towards the radical cations of single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The rate constants were determined to be 3.7-6.4 x 10(9), 4.8-5.5 x 10(8) and 8.8-10.3 x 10(8) M-1.sec(-1) for the repair reactions of oxidative radical of poly C and radical cations of ssDNA and dsDNA, respectively. The result of this study together with those of our previous studies demonstrates that PPGs and their analogues can fast repair not only the damage of deoxynucleoside and deoxynucleotide but also the damage of integral DNA, with the latter being closer to a cellular condition.
Subject AreaPhysics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000252718200002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7729
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorZheng, RL (reprint author), Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China
Recommended Citation
GB/T 7714
Shi, YM,Wang, WF,Huang, CY,et al. Fast repair of oxidative DNA damage by phenylpropanoid glycosides and their analogues[J]. MUTAGENESIS,2008,23(1):19.
APA Shi, YM.,Wang, WF.,Huang, CY.,Jia, ZJ.,Yao, SD.,...&Zheng, RL .(2008).Fast repair of oxidative DNA damage by phenylpropanoid glycosides and their analogues.MUTAGENESIS,23(1),19.
MLA Shi, YM,et al."Fast repair of oxidative DNA damage by phenylpropanoid glycosides and their analogues".MUTAGENESIS 23.1(2008):19.
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