Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas | |
| Zhao, J; Qi, YJ(漆玉金）; Dai, QS（代秋声）; Zhang, XZ; Qu, XM; Huang, J; Liu, XD; Liu, XD (reprint author), Fudan Univ, Huashan Hosp, Dept Nucl Med, Shanghai 200040, Peoples R China | |
| 2008 | |
| Source Publication | NUCLEAR SCIENCE AND TECHNIQUES
 |
| ISSN | 1001-8042 |
| Volume | 19Issue:2Pages:105 |
| Abstract | In this paper, (99m)Tc-TRODAT-1 Micro-SPECT (single-photon emission computed tomography) was used for imaging dopamine transporter (DAT) in retinas and to investigate the changes of DAT in retinas of pigs with form deprivation myopia. Pigmented guinea pigs aged 3 weeks were devided into form deprivation myopia (FDM) group (n=6) and normal control group (n=6). The test group wore translucent goggles randomly for 4 weeks, and both groups underwent biometric measurement (refraction and axial length) before and after the experiment. Micro-SPECT retinas imaging was performed at the 4(th) week after injection of (99m)Tc-TRODAT-1. The retinas were clearly resolved in the images. The ratio of (99m)Tc-TRODAT-1 uptake in the myopic retinas (11.55 +/- 2.80) was 3.64 +/- 1.40 lower than that in the control eye (15.20 +/- 1.98), and 2.35 +/- 1.05 lower than that in the fellow eyes (13.90 +/- 2.04). The results showed that (99m)Tc-TRODAT-1 Micro-SPECT eye imaging can be used to trace the distribution and changes of DAT in retina, and DAT in the myopic retinas were lower than that in the normal control eyes and fellow eyes. Micro-SPECT may provide a new approach for further studies on the role of dopamine system in the experimental myopia. |
| Subject Area | Physics |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000256955100009 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/7730 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Corresponding Author | Liu, XD (reprint author), Fudan Univ, Huashan Hosp, Dept Nucl Med, Shanghai 200040, Peoples R China |
| Recommended Citation GB/T 7714 | Zhao, J,Qi, YJ,Dai, QS,et al. Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas[J]. NUCLEAR SCIENCE AND TECHNIQUES,2008,19(2):105. |
| APA | Zhao, J.,Qi, YJ.,Dai, QS.,Zhang, XZ.,Qu, XM.,...&Liu, XD .(2008).Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas.NUCLEAR SCIENCE AND TECHNIQUES,19(2),105. |
| MLA | Zhao, J,et al."Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas".NUCLEAR SCIENCE AND TECHNIQUES 19.2(2008):105. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Feasibility of (99m)（393KB） | 开放获取 | -- | View Download | |||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment