CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas
Zhao, J; Qi, YJ(漆玉金); Dai, QS(代秋声); Zhang, XZ; Qu, XM; Huang, J; Liu, XD; Liu, XD (reprint author), Fudan Univ, Huashan Hosp, Dept Nucl Med, Shanghai 200040, Peoples R China
2008
Source PublicationNUCLEAR SCIENCE AND TECHNIQUES
ISSN1001-8042
Volume19Issue:2Pages:105
AbstractIn this paper, (99m)Tc-TRODAT-1 Micro-SPECT (single-photon emission computed tomography) was used for imaging dopamine transporter (DAT) in retinas and to investigate the changes of DAT in retinas of pigs with form deprivation myopia. Pigmented guinea pigs aged 3 weeks were devided into form deprivation myopia (FDM) group (n=6) and normal control group (n=6). The test group wore translucent goggles randomly for 4 weeks, and both groups underwent biometric measurement (refraction and axial length) before and after the experiment. Micro-SPECT retinas imaging was performed at the 4(th) week after injection of (99m)Tc-TRODAT-1. The retinas were clearly resolved in the images. The ratio of (99m)Tc-TRODAT-1 uptake in the myopic retinas (11.55 +/- 2.80) was 3.64 +/- 1.40 lower than that in the control eye (15.20 +/- 1.98), and 2.35 +/- 1.05 lower than that in the fellow eyes (13.90 +/- 2.04). The results showed that (99m)Tc-TRODAT-1 Micro-SPECT eye imaging can be used to trace the distribution and changes of DAT in retina, and DAT in the myopic retinas were lower than that in the normal control eyes and fellow eyes. Micro-SPECT may provide a new approach for further studies on the role of dopamine system in the experimental myopia.
Subject AreaPhysics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000256955100009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7730
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorLiu, XD (reprint author), Fudan Univ, Huashan Hosp, Dept Nucl Med, Shanghai 200040, Peoples R China
Recommended Citation
GB/T 7714
Zhao, J,Qi, YJ,Dai, QS,et al. Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas[J]. NUCLEAR SCIENCE AND TECHNIQUES,2008,19(2):105.
APA Zhao, J.,Qi, YJ.,Dai, QS.,Zhang, XZ.,Qu, XM.,...&Liu, XD .(2008).Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas.NUCLEAR SCIENCE AND TECHNIQUES,19(2),105.
MLA Zhao, J,et al."Feasibility of (99m)Tc-TRODAT-1 Micro-SPECT imaging of dopamine transporter in animal retinas".NUCLEAR SCIENCE AND TECHNIQUES 19.2(2008):105.
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