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Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier
Sun, HW(孙汉文); Zhang, LY; Zhu, XJ; Kong, CY; Zhang, CL; Yao, S(姚思德); Sun, HW (reprint author), Dezhou Univ, Dept Chem, Dezhou 253023, Peoples R China
2009
Source PublicationSCIENCE IN CHINA SERIES B-CHEMISTRY
ISSN1006-9291
Volume52Issue:1Pages:69
AbstractOne-pot synthesis of magnetic nanogels with excellent biocompatibility via the photochemical method is reported in this paper. Poly(PEGMA) modified superparamagnetic nanogels (poly(PEGMA) magnetic nanogels) were synthesized by in-situ polymerization using poly(ethylene glycol) methacrylate (PEGMA) as the monomer and N, N'-methylene-bis-(acrylamide) (MBA) as the cross-linking agent in magnetite aqueous suspension under UV irradiation. The surface functional groups and components of magnetic nanogels were analyzed by Fourier transform infrared spectroscopy (FTIR) and a thermogravimetric analyzer (TGA). The results indicated that the poly(PEGMA) magnetic nanogels were synthesized successfully by coating poly(PEGMA) on the Fe(3)O(4) nanoparticles under UV irradiation, and the Fe(3)O(4) nanoparticles content in this nanogels was above 50 wt%. The morphology, size, zeta-potential and magnetic property were also characterized. The magnetic nanogels had a nearly spherical shape and core-shell structure, the average size in aqueous system measured by photon correlation spectroscopy (PCS) was 68.4 nm, which was much bigger than that in the dry state, the nanogels behaved superparamagnetically with saturated magnetization of 58.6 emu/g, and the zeta-potential was -16.3--17.3 mV at physiological pH (6.8-7.4) which could help to maintain stability in blood. The preliminary application as drug carrier was made and the doxorubicin-loaded magnetic nanogels had an excellent property in slow-release. The experiment indicated that the magnetic nanogel was an ideal candidate carrier in target drug delivery systems and other biomedical application.
Subject AreaChemistry
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000262439700010
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7803
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorSun, HW (reprint author), Dezhou Univ, Dept Chem, Dezhou 253023, Peoples R China
Recommended Citation
GB/T 7714
Sun, HW,Zhang, LY,Zhu, XJ,et al. Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2009,52(1):69.
APA Sun, HW.,Zhang, LY.,Zhu, XJ.,Kong, CY.,Zhang, CL.,...&Sun, HW .(2009).Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier.SCIENCE IN CHINA SERIES B-CHEMISTRY,52(1),69.
MLA Sun, HW,et al."Poly(PEGMA) magnetic nanogels: preparation via photochemical method, characterization and application as drug carrier".SCIENCE IN CHINA SERIES B-CHEMISTRY 52.1(2009):69.
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