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Quantitative analysis of nucleotide mixtures with terahertz time domain spectroscopy
Zhang, ZY(张增艳); Xiao, TQ(肖体乔); Zhao, HW(赵红卫); Yu, XH(余笑寒); Xi, ZJ(席再军); Xu, HJ(徐洪杰); Xiao, TQ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2008
Source PublicationSPECTROSCOPY AND SPECTRAL ANALYSIS
ISSN1000-0593
Volume28Issue:9Pages:1990
AbstractAdenosine, thymidine, guanosine, cytidine and uridine form the building blocks of ribose nucleic acid (RNA) and deoxyribose nucleic acid (DNA). Nucleosides and their derivants are all have biological activities. Some of them can be used as medicine directly or as materials to synthesize other medicines. It is meaningful to detect the component and content in nucleosides mixtures. In the present paper, components and contents of the mixtures of adenosine, thymidine, guanosine, cytidine and uridine were analyzed. THz absorption spectra of pure nucleosides were set as standard spectra. The mixture's absorption Spectra were analyzed by linear regression with non-negative constraint to identify the components and their relative content in the mixtures. The experimental and analyzing results show that it is simple and effective to get the components and their relative percentage in the mixtures by terahertz time domain spectroscopy with a relative error less than 10%. Component which is absent could be excluded exactly by this method, and the error sources were also analyzed. All the experiments and analysis confirms that this method is of no damage or contamination to the sample. This means that it will be a simple, effective and new method in biochemical materials analysis, which extends the application field of THz-TDS.
Subject AreaEngineering ; Environmental Sciences & Ecology
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000259688600009
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7808
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorXiao, TQ (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Zhang, ZY,Xiao, TQ,Zhao, HW,et al. Quantitative analysis of nucleotide mixtures with terahertz time domain spectroscopy[J]. SPECTROSCOPY AND SPECTRAL ANALYSIS,2008,28(9):1990.
APA Zhang, ZY.,Xiao, TQ.,Zhao, HW.,Yu, XH.,Xi, ZJ.,...&Xiao, TQ .(2008).Quantitative analysis of nucleotide mixtures with terahertz time domain spectroscopy.SPECTROSCOPY AND SPECTRAL ANALYSIS,28(9),1990.
MLA Zhang, ZY,et al."Quantitative analysis of nucleotide mixtures with terahertz time domain spectroscopy".SPECTROSCOPY AND SPECTRAL ANALYSIS 28.9(2008):1990.
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