Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy | |
| Liang, S（梁胜）; Wang, YX（汪勇先）; Yu, JF（于俊峰）; Zhang, CF（张春富）; Xia, JY; Yin, DZ（尹端沚）; Wang, YX (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China | |
| 2007 | |
| Source Publication | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
 |
| ISSN | 0957-4530 |
| Volume | 18Issue:12Pages:2297 |
| Abstract | Amino-functionalized superparamagnetic iron oxide nanoparticles (SPION) were synthesized by coprecipitation method. The particles were characterized by X-ray diffraction (XRD), vibrating sample magnetometer (VSM), scanning electron micrographs (SEM), transmission electron micrographs (TEM) and atomic force micrographs (AFM). The size of the modified particles varied in the range 10-15 nm and did not change significantly after modification. Hepama-1, an excellent humanized monoclonal antibody directed against liver cancer, was conjugated to the SPION to prepare immuno-magnetic nanoparticles (IMN). A direct labeling method was employed to radiolabel IMN with rhenium-188. The radiolabeling efficiency was about 90% with good in vitro stability. Re-188 labeled IMN could markedly kill SMMC-7721 liver cancer cells. Such SPION might be very useful for bio-magnetically targeted radiotherapy in liver cancer treatment. |
| Subject Area | Physics |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000250999500008 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/7843 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Corresponding Author | Wang, YX (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China |
| Recommended Citation GB/T 7714 | Liang, S,Wang, YX,Yu, JF,et al. Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2007,18(12):2297. |
| APA | Liang, S.,Wang, YX.,Yu, JF.,Zhang, CF.,Xia, JY.,...&Wang, YX .(2007).Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,18(12),2297. |
| MLA | Liang, S,et al."Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 18.12(2007):2297. |
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