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Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy
Liang, S(梁胜); Wang, YX(汪勇先); Yu, JF(于俊峰); Zhang, CF(张春富); Xia, JY; Yin, DZ(尹端沚); Wang, YX (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China
2007
Source PublicationJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
ISSN0957-4530
Volume18Issue:12Pages:2297
AbstractAmino-functionalized superparamagnetic iron oxide nanoparticles (SPION) were synthesized by coprecipitation method. The particles were characterized by X-ray diffraction (XRD), vibrating sample magnetometer (VSM), scanning electron micrographs (SEM), transmission electron micrographs (TEM) and atomic force micrographs (AFM). The size of the modified particles varied in the range 10-15 nm and did not change significantly after modification. Hepama-1, an excellent humanized monoclonal antibody directed against liver cancer, was conjugated to the SPION to prepare immuno-magnetic nanoparticles (IMN). A direct labeling method was employed to radiolabel IMN with rhenium-188. The radiolabeling efficiency was about 90% with good in vitro stability. Re-188 labeled IMN could markedly kill SMMC-7721 liver cancer cells. Such SPION might be very useful for bio-magnetically targeted radiotherapy in liver cancer treatment.
Subject AreaPhysics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000250999500008
Citation statistics
Cited Times:71[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7843
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorWang, YX (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Liang, S,Wang, YX,Yu, JF,et al. Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2007,18(12):2297.
APA Liang, S.,Wang, YX.,Yu, JF.,Zhang, CF.,Xia, JY.,...&Wang, YX .(2007).Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,18(12),2297.
MLA Liang, S,et al."Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 18.12(2007):2297.
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