CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating
Su, YY; He, Y; Lu, HT; Sai, LM; Li, QN(李晴暖); Li, WX(李文新); Wang, LH; Shen, PP; Huang, Q(黄庆); Fan, CH(樊春海); Huang, Q (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Jialuo Rd 2019, Shanghai 201800, Peoples R China
2009
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume30Issue:1Pages:19
AbstractIn this report, we evaluated the cytotoxicity of a series of quantum dots (QDs) directly synthesized in aqueous phase, i.e., thiols-stabilized CdTe, CdTe/CdS core-shell structured and CdTe/CdS/ZnS core-shell-shell structured QDs, with a variety of cell lines including K562 and HEK293T. We have demonstrated that the CdTe QDs are highly toxic for cells due to the release of cadmium ions. Epitaxial growth of a CdS layer reduces the cytotoxicity of QDs to a small extent. However, the presence of a ZnS outlayer greatly improves the biocompatibility of QDs, with no observed cytotoxicity even at very high concentration and long-time exposure in cells. Our systematic investigation clearly shows that the cytotoxicity of QDs can be modulated through elaborate surface coatings and that the CdTe/CdS/ZnS core-shell-shell structured QDs directly synthesized in aqueous phase are highly promising biological fluorescent probes for cellular imaging. (C) 2008 Elsevier Ltd. All rights reserved.
Subject AreaEngineering ; Materials Science
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000261139100003
Citation statistics
Cited Times:263[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7855
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorHuang, Q (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Jialuo Rd 2019, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Su, YY,He, Y,Lu, HT,et al. The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating[J]. BIOMATERIALS,2009,30(1):19.
APA Su, YY.,He, Y.,Lu, HT.,Sai, LM.,Li, QN.,...&Huang, Q .(2009).The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating.BIOMATERIALS,30(1),19.
MLA Su, YY,et al."The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating".BIOMATERIALS 30.1(2009):19.
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