Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating | |
| Su, YY; He, Y; Lu, HT; Sai, LM; Li, QN（李晴暖）; Li, WX（李文新）; Wang, LH; Shen, PP; Huang, Q（黄庆）; Fan, CH（樊春海）; Huang, Q (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Jialuo Rd 2019, Shanghai 201800, Peoples R China | |
| 2009 | |
| Source Publication | BIOMATERIALS
 |
| ISSN | 0142-9612 |
| Volume | 30Issue:1Pages:19 |
| Abstract | In this report, we evaluated the cytotoxicity of a series of quantum dots (QDs) directly synthesized in aqueous phase, i.e., thiols-stabilized CdTe, CdTe/CdS core-shell structured and CdTe/CdS/ZnS core-shell-shell structured QDs, with a variety of cell lines including K562 and HEK293T. We have demonstrated that the CdTe QDs are highly toxic for cells due to the release of cadmium ions. Epitaxial growth of a CdS layer reduces the cytotoxicity of QDs to a small extent. However, the presence of a ZnS outlayer greatly improves the biocompatibility of QDs, with no observed cytotoxicity even at very high concentration and long-time exposure in cells. Our systematic investigation clearly shows that the cytotoxicity of QDs can be modulated through elaborate surface coatings and that the CdTe/CdS/ZnS core-shell-shell structured QDs directly synthesized in aqueous phase are highly promising biological fluorescent probes for cellular imaging. (C) 2008 Elsevier Ltd. All rights reserved. |
| Subject Area | Engineering ; Materials Science |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000261139100003 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/7855 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Corresponding Author | Huang, Q (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Jialuo Rd 2019, Shanghai 201800, Peoples R China |
| Recommended Citation GB/T 7714 | Su, YY,He, Y,Lu, HT,et al. The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating[J]. BIOMATERIALS,2009,30(1):19. |
| APA | Su, YY.,He, Y.,Lu, HT.,Sai, LM.,Li, QN.,...&Huang, Q .(2009).The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating.BIOMATERIALS,30(1),19. |
| MLA | Su, YY,et al."The cytotoxicity of cadmium based, aqueous phase - Synthesized, quantum dots and its modulation by surface coating".BIOMATERIALS 30.1(2009):19. |
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