CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
The electrochemical DNA biosensor
Zhang, J(张炯); Wan, Y(万莹); Wang, LH(王丽华); Song, SP(宋世平); Fan, CH(樊春海); Zhang, J (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
AbstractSequence-specific detection of either genetically or pathogenically associated nucleic acids has become increasingly important for applications including point-of-care diagnostics, antiterrorism; environmental monitoring and forensic analysis. Therefore, it is highly desirable to develop DNA detection methods with high sensitivity and selectivity, as well as speed, which has motivated the development of various optical, electronic and acoustic DNA biosensors. Because electrochemical detectors are inexpensive, portable and power-saving, electrochemical DNA biosensors have been widely recognized to be a highly promising approach to detect clinical, environmental and security relevant nucleic acids, especially when time, money or resources are limited. The development of the research on electrochemical DNA biosensor, one of the most important branch of DNA biosensors, is reviewed. A typical electrochemical DNA sensor involves an electrode and surface-confined capture probe DNA. Upon hybridization of the immobilized probes to the sequence-specific target DNA, redox labels that either intercalatively bind to the hybridized double-stranded DNA or covalently tagged to DNA strands generate corresponding electrochemical signals. The immobilization of DNA probes and electrochemical transduction of DNA hybridization. are summarized.
Subject AreaPhysics
Indexed BySCI
Funding Project应物所项目组
WOS IDWOS:000250283200016
Citation statistics
Document Type期刊论文
Corresponding AuthorZhang, J (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Zhang, J,Wan, Y,Wang, LH,et al. The electrochemical DNA biosensor[J]. PROGRESS IN CHEMISTRY,2007,19(10):1576.
APA Zhang, J,Wan, Y,Wang, LH,Song, SP,Fan, CH,&Zhang, J .(2007).The electrochemical DNA biosensor.PROGRESS IN CHEMISTRY,19(10),1576.
MLA Zhang, J,et al."The electrochemical DNA biosensor".PROGRESS IN CHEMISTRY 19.10(2007):1576.
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