Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| The electrochemical DNA biosensor | |
| Zhang, J(张炯）; Wan, Y（万莹）; Wang, LH（王丽华）; Song, SP（宋世平）; Fan, CH（樊春海）; Zhang, J (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China | |
| 2007 | |
| Source Publication | PROGRESS IN CHEMISTRY
 |
| ISSN | 1005-281X |
| Volume | 19Issue:10Pages:1576 |
| Abstract | Sequence-specific detection of either genetically or pathogenically associated nucleic acids has become increasingly important for applications including point-of-care diagnostics, antiterrorism; environmental monitoring and forensic analysis. Therefore, it is highly desirable to develop DNA detection methods with high sensitivity and selectivity, as well as speed, which has motivated the development of various optical, electronic and acoustic DNA biosensors. Because electrochemical detectors are inexpensive, portable and power-saving, electrochemical DNA biosensors have been widely recognized to be a highly promising approach to detect clinical, environmental and security relevant nucleic acids, especially when time, money or resources are limited. The development of the research on electrochemical DNA biosensor, one of the most important branch of DNA biosensors, is reviewed. A typical electrochemical DNA sensor involves an electrode and surface-confined capture probe DNA. Upon hybridization of the immobilized probes to the sequence-specific target DNA, redox labels that either intercalatively bind to the hybridized double-stranded DNA or covalently tagged to DNA strands generate corresponding electrochemical signals. The immobilization of DNA probes and electrochemical transduction of DNA hybridization. are summarized. |
| Subject Area | Physics |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000250283200016 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/7859 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Corresponding Author | Zhang, J (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, J,Wan, Y,Wang, LH,et al. The electrochemical DNA biosensor[J]. PROGRESS IN CHEMISTRY,2007,19(10):1576. |
| APA | Zhang, J,Wan, Y,Wang, LH,Song, SP,Fan, CH,&Zhang, J .(2007).The electrochemical DNA biosensor.PROGRESS IN CHEMISTRY,19(10),1576. |
| MLA | Zhang, J,et al."The electrochemical DNA biosensor".PROGRESS IN CHEMISTRY 19.10(2007):1576. |
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