CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures
Zhang, J; Wang, LH(王丽华); Pan, D; Song, SP(宋世平); Boey, FYC; Zhang, H; Fan, CH(樊春海); Fan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2008
Source PublicationSMALL
ISSN1613-6810
Volume4Issue:8Pages:1196
AbstractA novel bioassay strategy is designed to detect small-molecule targets such as cocaine, potassium, and adenosine, based on gold nanoparticles (AuNPs) and engineered DNA aptamers. In this design, an aptamer is engineered to be two pieces of random, coil-like single-stranded DNA, which reassembles into the intact aptamer tertiary structure in the presence of the specific target. AuNPs can effectively differentiate between these two states via their characteristic surface-plasmon resonance-based color change. Using this method, cocaine in the low-micromolar range is selectively detected within minutes. This strategy is also shown to be generic and applicable to the detection of several other small-molecule tat-gets.
Subject AreaChemistry ; Nuclear Science & Technology ; Physics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000258566400029
Citation statistics
Cited Times:327[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/7874
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorFan, CH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Zhang, J,Wang, LH,Pan, D,et al. Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures[J]. SMALL,2008,4(8):1196.
APA Zhang, J.,Wang, LH.,Pan, D.,Song, SP.,Boey, FYC.,...&Fan, CH .(2008).Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures.SMALL,4(8),1196.
MLA Zhang, J,et al."Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures".SMALL 4.8(2008):1196.
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