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Acceleration of alpha-synuclein aggregation by homologous peptides
Du, HN; Li, HT; Zhang, F(张锋); Lin, XJ; Shi, JH; Shi, YH; Ji, LN; Hu, J(胡钧); Lin, DH; Hu, HY; Hu, HY (reprint author), Chinese Acad Sci, Key Lab Prote, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China
2006
Source PublicationFEBS LETTERS
ISSN0014-5793
Volume580Issue:15Pages:3657
Abstractalpha-Synuclein (alpha-Syn), amyloid beta-protein and prion protein are among the amyloidogenic proteins that are associated with the neurodegenerative diseases. These three proteins share a homologous region with a consensus sequence mainly consisting of glycine, alanine and valine residues (accordingly named as the GAV motif), which was proposed to be the critical core for the fibrillization and cytotoxicity. To understand the role of the GAV motif in protein amyloidogenesis, we studied the effects of the homologous peptides corresponding to the sequence of GAV motif region (residues 66-74) on alpha-Syn aggregation. The result shows that these peptides can promote fibrillization of wild-type a-Syn and induce that of the charge-incorporated mutants but not the GAV-deficient alpha-Syn mutant. The acceleration of a-Syn aggregation by the homologous peptides is under a sequence-specific manner. The interplay between the GAV peptide and the core regions in alpha-Syn may accelerate the aggregation process and stabilize the fibrils. This finding provides clues for developing peptide mimics that could promote transforming the toxic oligomers or protofibrils into the inert mature fibrils. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
KeywordAlpha-synuclein Gav Motif Aggregation Fibrillization Homologous Peptide Parkinson's Disease
Subject AreaPhysics
Indexed Bysci
Language英语
Funding Project应物所项目组
WOS IDWOS:000238691600014
Citation statistics
Cited Times:21[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8007
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorHu, HY (reprint author), Chinese Acad Sci, Key Lab Prote, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai, Peoples R China
Recommended Citation
GB/T 7714
Du, HN,Li, HT,Zhang, F,et al. Acceleration of alpha-synuclein aggregation by homologous peptides[J]. FEBS LETTERS,2006,580(15):3657.
APA Du, HN.,Li, HT.,Zhang, F.,Lin, XJ.,Shi, JH.,...&Hu, HY .(2006).Acceleration of alpha-synuclein aggregation by homologous peptides.FEBS LETTERS,580(15),3657.
MLA Du, HN,et al."Acceleration of alpha-synuclein aggregation by homologous peptides".FEBS LETTERS 580.15(2006):3657.
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