CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
An unstructured region is required by GAV homologue for the fibrillization of host proteins
Ji, LN; Du, HN; Zhang, F(张锋); Li, HT(李洪涛); Luo, XY; Hu, J(胡钧); Hu, HY; Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Prote, Shanghai 200031, Peoples R China
2005
Source PublicationPROTEIN JOURNAL
ISSN1572-3887
Volume24Issue:4Pages:209
AbstractAccumulating evidence shows that some amyloidogenic proteins contain core sequences, which are critical for their fibrillization. Core sequences of alpha-synuclein, beta-amyloid peptide and prion protein usually reside in their unfolded regions and share a conserved consensus (VGGAVVAGV) designated as GAV homologue. Here we investigate the role of unfolded regions in fibrillization after GAV homologue is attached to the C-terminus or inserted into the loop regions of different host proteins, namely alpha -Syn(1-65), gamma-synuclein, E. coli thioredoxin and immunoglobulin G binding B1 domain of streptococcal protein G. The results imply that an unstructured region is required by GAV homologue for the fibrillization of host proteins. A number of amyloidogenic proteins with core sequences located in unstructured regions are summarized and discussed in details. The finding may provide further insight into the elucidating of the molecular mechanism underlying the fibrillization of alpha-Syn, A beta and PrP as well as other amyloidogenic proteins.
KeywordAlpha-synuclein Amyloidogenic Protein Fibrillization Gav Homologue Unstructured Regions
Subject AreaPhysics
Indexed Bysci
Language英语
Funding Project应物所项目组
WOS IDWOS:000233246300002
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8009
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorHu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Prote, Shanghai 200031, Peoples R China
Recommended Citation
GB/T 7714
Ji, LN,Du, HN,Zhang, F,et al. An unstructured region is required by GAV homologue for the fibrillization of host proteins[J]. PROTEIN JOURNAL,2005,24(4):209.
APA Ji, LN.,Du, HN.,Zhang, F.,Li, HT.,Luo, XY.,...&Hu, HY .(2005).An unstructured region is required by GAV homologue for the fibrillization of host proteins.PROTEIN JOURNAL,24(4),209.
MLA Ji, LN,et al."An unstructured region is required by GAV homologue for the fibrillization of host proteins".PROTEIN JOURNAL 24.4(2005):209.
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