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| An unstructured region is required by GAV homologue for the fibrillization of host proteins | |
| Ji, LN; Du, HN; Zhang, F（张锋）; Li, HT（李洪涛）; Luo, XY; Hu, J（胡钧）; Hu, HY; Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Prote, Shanghai 200031, Peoples R China | |
| 2005 | |
| Source Publication | PROTEIN JOURNAL
 |
| ISSN | 1572-3887 |
| Volume | 24Issue:4Pages:209 |
| Abstract | Accumulating evidence shows that some amyloidogenic proteins contain core sequences, which are critical for their fibrillization. Core sequences of alpha-synuclein, beta-amyloid peptide and prion protein usually reside in their unfolded regions and share a conserved consensus (VGGAVVAGV) designated as GAV homologue. Here we investigate the role of unfolded regions in fibrillization after GAV homologue is attached to the C-terminus or inserted into the loop regions of different host proteins, namely alpha -Syn(1-65), gamma-synuclein, E. coli thioredoxin and immunoglobulin G binding B1 domain of streptococcal protein G. The results imply that an unstructured region is required by GAV homologue for the fibrillization of host proteins. A number of amyloidogenic proteins with core sequences located in unstructured regions are summarized and discussed in details. The finding may provide further insight into the elucidating of the molecular mechanism underlying the fibrillization of alpha-Syn, A beta and PrP as well as other amyloidogenic proteins. |
| Keyword | Alpha-synuclein Amyloidogenic Protein Fibrillization Gav Homologue Unstructured Regions |
| Subject Area | Physics |
| Indexed By | sci |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000233246300002 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/8009 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Corresponding Author | Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Prote, Shanghai 200031, Peoples R China |
| Recommended Citation GB/T 7714 | Ji, LN,Du, HN,Zhang, F,et al. An unstructured region is required by GAV homologue for the fibrillization of host proteins[J]. PROTEIN JOURNAL,2005,24(4):209. |
| APA | Ji, LN.,Du, HN.,Zhang, F.,Li, HT.,Luo, XY.,...&Hu, HY .(2005).An unstructured region is required by GAV homologue for the fibrillization of host proteins.PROTEIN JOURNAL,24(4),209. |
| MLA | Ji, LN,et al."An unstructured region is required by GAV homologue for the fibrillization of host proteins".PROTEIN JOURNAL 24.4(2005):209. |
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