CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Depletion of FKBP does not affect the interaction between isolated ryanodine receptors
Hu, XF; Liang, X; Chen, KY; Zhu, PH; Hu, J(胡钧); Hu, J (reprint author), Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, Bio X Life Sci Res Ctr, 1954 Hua Shan Rd, Shanghai 200030, Peoples R China
2005
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN0006-291X
Volume336Issue:1Pages:128
AbstractThe ryanodine receptors/calcium release channels (RyRs) usually form two dimensional regular lattices in the endoplasmic/sarcoplasmic reticulum membranes. The native RyR is associated with many auxiliary proteins, including FKBP. It has been indicated that FKBP may play a role in the intermolecular interaction and coupled gating of neighboring RyRs. However, a more recent study shows that FKBP 12 is not involved in the physical linkage between neighboring RyR1s. In the present work, the effect of FKBP 12 on the interaction between RyR Is isolated from rabbit skeletal muscle was investigated in an aqueous medium with photon correlation spectroscopy. We found that the depletion of FKBP 12 did not affect the oligomerization of RyR Is in the medium containing different [KCI] or under different channel functional states. No evidence is obtained for the involvement of FKBP12 in the intermolecular interaction between RyR1s. (c) 2005 Elsevier Inc. All rights reserved.
KeywordRyanodine Receptor/calcium Release Channel Ryr Array Coupled Gating Intermolecular Interaction Fkbp12 Modulation Photon Correlation Spectroscopy
Subject AreaPhysics
Indexed Bysci
Language英语
Funding Project应物所项目组
WOS IDWOS:000231941500020
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8035
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorHu, J (reprint author), Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, Bio X Life Sci Res Ctr, 1954 Hua Shan Rd, Shanghai 200030, Peoples R China
Recommended Citation
GB/T 7714
Hu, XF,Liang, X,Chen, KY,et al. Depletion of FKBP does not affect the interaction between isolated ryanodine receptors[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2005,336(1):128.
APA Hu, XF,Liang, X,Chen, KY,Zhu, PH,Hu, J,&Hu, J .(2005).Depletion of FKBP does not affect the interaction between isolated ryanodine receptors.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,336(1),128.
MLA Hu, XF,et al."Depletion of FKBP does not affect the interaction between isolated ryanodine receptors".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 336.1(2005):128.
Files in This Item: Download All
File Name/Size DocType Version Access License
Depletion of FKBP do(246KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Hu, XF]'s Articles
[Liang, X]'s Articles
[Chen, KY]'s Articles
Baidu academic
Similar articles in Baidu academic
[Hu, XF]'s Articles
[Liang, X]'s Articles
[Chen, KY]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Hu, XF]'s Articles
[Liang, X]'s Articles
[Chen, KY]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Depletion of FKBP does not affect the interaction between isolated ryanodine receptors.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.