CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Direct measurement of compression spring constant of single DNA molecule with AFM
Zhou, XF(周星飞); An, HJ; Guo, YC; Sun, JL; Li, MQ(李民乾); Hu, J(胡钧); Sun, JL (reprint author), Shanghai Jiao Tong Univ, BioX Life Sci Res Ctr, Shanghai 200030, Peoples R China
2005
Source PublicationCHINESE SCIENCE BULLETIN
ISSN1001-6538
Volume50Issue:10Pages:954
AbstractIn this paper, a new approach is demonstrated to measure the compression elasticity of single biomolecule in small force regime (< 0.5 nN) using vibrating mode scanning polarization force microscopy (VSPFM). With this method we investigate the compression elasticity of a single DNA molecule in the radial direction (perpendicular to DNA strands). The radial deformation of DNA molecules deposited on mica surface is shown to be able to reach about 50% under external load, and this remarkable deformation is reversible. In addition, the compression spring constant of DNA molecules is estimated to be about 0.6 nN/nm according to the height-force curves.
KeywordAtomic Force Microscopy Single Dna Molecule Elasticity
Subject AreaInstruments & Instrumentation ; Nuclear Science & Technology ; Physics
Indexed Bysci
Language英语
Funding Project应物所项目组
WOS IDWOS:000230696700003
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8037
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorSun, JL (reprint author), Shanghai Jiao Tong Univ, BioX Life Sci Res Ctr, Shanghai 200030, Peoples R China
Recommended Citation
GB/T 7714
Zhou, XF,An, HJ,Guo, YC,et al. Direct measurement of compression spring constant of single DNA molecule with AFM[J]. CHINESE SCIENCE BULLETIN,2005,50(10):954.
APA Zhou, XF.,An, HJ.,Guo, YC.,Sun, JL.,Li, MQ.,...&Sun, JL .(2005).Direct measurement of compression spring constant of single DNA molecule with AFM.CHINESE SCIENCE BULLETIN,50(10),954.
MLA Zhou, XF,et al."Direct measurement of compression spring constant of single DNA molecule with AFM".CHINESE SCIENCE BULLETIN 50.10(2005):954.
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