Electrochemical interrogation of DNA monolayers on gold surfaces

CAS OpenIR > 中科院上海应用物理研究所2004-2010年

	Electrochemical interrogation of DNA monolayers on gold surfaces
	Lao, RJ; Song, SP（宋世平）; Wu, HP; Wang, LH（王丽华）; Zhang, ZZ; He, L; Fan, CH（樊春海）; Zhang, ZZ (reprint author), Shanghai Jiao Tong Univ, BioX Life Sci Res Ctr, Shanghai 200030, Peoples R China
	2005
Source Publication	ANALYTICAL CHEMISTRY
ISSN	0003-2700
Volume	77 Issue:19 Pages:6475
Abstract	In this report, we systematically investigated DNA immobilization at gold surfaces with electrochemical techniques. Comparative cyclic voltammetric and chrono-coulometric studies suggested that DNA monolayers immobilized at gold surfaces were not homogeneous. Nonspecific Au-DNA interactions existed even with the treatment of mercaptobexanol, which was known to competitively remove loosely bound. DNA at gold surfaces. While both thiolated and nonthiolated DNA formed monolayers on gold surfaces, their hybridization abilities were distinctly different. In contrast to thiolated DNA probes, nonthiolated DNA probes immobilized at gold surfaces were essentially nonhybridizable. The experimental results presented here might be useful for the design of high-performance electrochemical DNA sensors.
Subject Area	Physics
Indexed By	sci
Language	英语
Funding Project	应物所项目组
WOS ID	WOS:000232443700061
Citation statistics	Cited Times:203[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/8049
Collection	中科院上海应用物理研究所2004-2010年
Corresponding Author	Zhang, ZZ (reprint author), Shanghai Jiao Tong Univ, BioX Life Sci Res Ctr, Shanghai 200030, Peoples R China
Recommended Citation GB/T 7714	Lao, RJ,Song, SP,Wu, HP,et al. Electrochemical interrogation of DNA monolayers on gold surfaces[J]. ANALYTICAL CHEMISTRY,2005,77(19):6475.
APA	Lao, RJ.,Song, SP.,Wu, HP.,Wang, LH.,Zhang, ZZ.,...&Zhang, ZZ .(2005).Electrochemical interrogation of DNA monolayers on gold surfaces.ANALYTICAL CHEMISTRY,77(19),6475.
MLA	Lao, RJ,et al."Electrochemical interrogation of DNA monolayers on gold surfaces".ANALYTICAL CHEMISTRY 77.19(2005):6475.

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