CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Electrochemical interrogation of DNA monolayers on gold surfaces
Lao, RJ; Song, SP(宋世平); Wu, HP; Wang, LH(王丽华); Zhang, ZZ; He, L; Fan, CH(樊春海); Zhang, ZZ (reprint author), Shanghai Jiao Tong Univ, BioX Life Sci Res Ctr, Shanghai 200030, Peoples R China
2005
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
Volume77Issue:19Pages:6475
AbstractIn this report, we systematically investigated DNA immobilization at gold surfaces with electrochemical techniques. Comparative cyclic voltammetric and chrono-coulometric studies suggested that DNA monolayers immobilized at gold surfaces were not homogeneous. Nonspecific Au-DNA interactions existed even with the treatment of mercaptobexanol, which was known to competitively remove loosely bound. DNA at gold surfaces. While both thiolated and nonthiolated DNA formed monolayers on gold surfaces, their hybridization abilities were distinctly different. In contrast to thiolated DNA probes, nonthiolated DNA probes immobilized at gold surfaces were essentially nonhybridizable. The experimental results presented here might be useful for the design of high-performance electrochemical DNA sensors.
Subject AreaPhysics
Indexed Bysci
Language英语
Funding Project应物所项目组
WOS IDWOS:000232443700061
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8049
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorZhang, ZZ (reprint author), Shanghai Jiao Tong Univ, BioX Life Sci Res Ctr, Shanghai 200030, Peoples R China
Recommended Citation
GB/T 7714
Lao, RJ,Song, SP,Wu, HP,et al. Electrochemical interrogation of DNA monolayers on gold surfaces[J]. ANALYTICAL CHEMISTRY,2005,77(19):6475.
APA Lao, RJ.,Song, SP.,Wu, HP.,Wang, LH.,Zhang, ZZ.,...&Zhang, ZZ .(2005).Electrochemical interrogation of DNA monolayers on gold surfaces.ANALYTICAL CHEMISTRY,77(19),6475.
MLA Lao, RJ,et al."Electrochemical interrogation of DNA monolayers on gold surfaces".ANALYTICAL CHEMISTRY 77.19(2005):6475.
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