CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Interactions between endostatin and vascular endothelial growth factor (VEGF) and inhibition of choroidal neovascularization
Wang, X; Xu, X; Tang, LS; Song, SP(宋世平); Fan, CH(樊春海); Xu, X (reprint author), Shanghai Jiao Tong Univ, Affiliated 1st Peoples Hosp, Shanghai 200080, Peoples R China
2007
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN1661-6596
Volume8Issue:1Pages:61
AbstractThis study was designed to evaluate the inhibitory effect of endostatin on choroidal neovascularization (CNV) in laser-induced rat model. Choroidal neovascularization was induced in Brown Norway (BN) rats by diode-laser photocoagulation. Rats were randomly divided into five groups (10 animals in each group): endostatin 20mg/kg group, endostatin 10mg/kg group, laser injury group, normal saline group and blank control group. The animals were treated with endostatin, normal saline, laser injury or without treatment on day 0 to day 13 after laser photocoagulation. On day 7 and 14 after laser photocoagulation, the CNV formation was assessed by fluorescein angiography and histopathological analysis. VEGF expression in retina was determined by immunohistochemical assay. In two endostatin groups, the incidence of CNV formation and the intensity of fluorescein leakage were reduced compared with the two control groups. No significant difference was found between laser injury group and normal saline group. The expression of VEGF reached peak at day 7 and then decreased from day 14 after photocoagulation. The expression of VEGF was significantly reduced in the two endostain groups than laser injury group in a dose-dependent way. Endostatin can inhibit the formation of experimental CNV in the rat. Down-regulation of VEGF expression could be one of the mechanisms underlying the inhibition of CNV by endostatin.
KeywordHoroidal Neovascularization Animal Model Laser Endostatin Vegf
Subject AreaBiochemistry & Molecular Biology
Indexed Bysci
Language英语
Funding Project应物所项目组
WOS IDWOS:000243883400006
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8081
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorXu, X (reprint author), Shanghai Jiao Tong Univ, Affiliated 1st Peoples Hosp, Shanghai 200080, Peoples R China
Recommended Citation
GB/T 7714
Wang, X,Xu, X,Tang, LS,et al. Interactions between endostatin and vascular endothelial growth factor (VEGF) and inhibition of choroidal neovascularization[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2007,8(1):61.
APA Wang, X,Xu, X,Tang, LS,Song, SP,Fan, CH,&Xu, X .(2007).Interactions between endostatin and vascular endothelial growth factor (VEGF) and inhibition of choroidal neovascularization.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,8(1),61.
MLA Wang, X,et al."Interactions between endostatin and vascular endothelial growth factor (VEGF) and inhibition of choroidal neovascularization".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 8.1(2007):61.
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