CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism
Lin, XJ; Zhang, F; Xie, YY; Bao, WJ; He, JH(何建华); Hu, HY; Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Proteom, 320 Yue Yang Rd, Shanghai 200031, Peoples R China
2006
Source PublicationBIOPOLYMERS
ISSN0006-3525
Volume83Issue:3Pages:226
Abstractalpha-Synuclein (alpha-Syn) has been identified as a component of intracellular fibrillar deposits in Parkinson's disease. Though the real pathogenesis is still unknown, many investigations have revealed that conformational alteration and fibril formation of alpha-Syn protein have an important role in causing the disease. In this work, we introduced the g-factor spectra of solid-state circular dichroism to estimate the secondary structure contents of alpha-Syn fragments in amyloids. Fourier-transform infrared (FTIR) was also applied to confirm the structural formation. The results suggest that the central hydrophobic region is critical for beta-sheet formation and the conformational alteration is the foundation of protein abnormal aggregation. The research provides a practical approach to estimate the secondary structure contents of protein amyloids and further insight into the relevance of structural transformation and amyloidogenesis. (c) 2006 Wiley Periodicals, Inc.
KeywordAlpha-synuclein Circular Dichroism G-factor Aggregation Gav Motif Ftir
Subject AreaPhysics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000240709800003
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8187
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorHu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Proteom, 320 Yue Yang Rd, Shanghai 200031, Peoples R China
Recommended Citation
GB/T 7714
Lin, XJ,Zhang, F,Xie, YY,et al. Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism[J]. BIOPOLYMERS,2006,83(3):226.
APA Lin, XJ.,Zhang, F.,Xie, YY.,Bao, WJ.,He, JH.,...&Hu, HY .(2006).Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism.BIOPOLYMERS,83(3),226.
MLA Lin, XJ,et al."Secondary structural formation of alpha-synuclein amyloids as revealed by g-factor of solid-state circular dichroism".BIOPOLYMERS 83.3(2006):226.
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