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Studies on reaction of amino acids and triplet thioxanthone derivatives by laser flash photolysis
Zhu, HP(朱红萍); Wang, WF(王文锋); Yao, SD(姚思德); Wang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2006
Source PublicationINVESTIGATIONAL NEW DRUGS
ISSN0167-6997
Volume24Issue:6Pages:465
AbstractExcitation of the thioxanthone derivatives (TXs), 2, 4-diethylthioxanthone (DETX) and 2-(2,3-epoxypropyloxy) thioxanthone (ETX) in acetonitrile/water mixture solution (1:1, v/v) upon 355 nm laser flash produced the triplet of TXs ((3)TXs*). Characteristic absorption spectra of (3)TXs*(590 nm) were recorded and rate constants of (3)TXs* quenched by O-2 and by its ground state were determined (9.8 x 10(9) M-1 s(-1), 7.3 x 10(9) M-1 s(-1) and 2.6 x 10(8) M-1 s(-1), 2.2 x 10(8) M-1 s(-1) respectively). The reactions of some amino acids oxidized by (3)TXs* were carried out. It has been found that tryptophan (Trp) and tyrosine (Tyr) can quench (3)TXs* via electron transfer process and related quenching rate constants were obtained. (3)TXs* induced protein damage was investigated using electrophoresis and significant levels of dimerisation were observed under aerobic and anaerobic conditions. The influence of photo-sensitizer's structure on photo-oxidation of amino acid and protein has been discussed.
KeywordThioxanthone Derivatives Anti-tumor Triplet State Amino Acid Hen Egg White Lysozyme
Subject AreaCrystallography ; Materials Science ; Physics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000239959400002
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8202
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorWang, WF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Zhu, HP,Wang, WF,Yao, SD,et al. Studies on reaction of amino acids and triplet thioxanthone derivatives by laser flash photolysis[J]. INVESTIGATIONAL NEW DRUGS,2006,24(6):465.
APA Zhu, HP,Wang, WF,Yao, SD,&Wang, WF .(2006).Studies on reaction of amino acids and triplet thioxanthone derivatives by laser flash photolysis.INVESTIGATIONAL NEW DRUGS,24(6),465.
MLA Zhu, HP,et al."Studies on reaction of amino acids and triplet thioxanthone derivatives by laser flash photolysis".INVESTIGATIONAL NEW DRUGS 24.6(2006):465.
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