CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Study of the disassembly-assembly process of alpha-synuclein fibrils by in situ atomic force microscopy
Tang, L(唐琳); Li, HT(李洪涛); Du, HN; Zhang, F; Hu, XF; Hu, HY; Tang, L (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Baojia Rd, Shanghai 201800, Peoples R China
2006
Source PublicationMICRON
ISSN0968-4328
Volume37Issue:7Pages:675
AbstractIn this report, we applied in situ atomic force microscopy (AFM) to study the dynamic process of disassembly-assembly of alpha-synuclein (alpha-Syn) fibrils in different solutions. Most of the mica-adsorbed alpha-Syn fibrils disassemble into small particles step-by-step on the mica surface in diluted solutions, yet a few short fibrils still extend to form longer fibrils. This process usually started randomly at the center of the long fibrils, which progressively disassemble into short fragments and small protein particles of varying size. Compared to disassembly, assembly happened infrequently when the protein concentration was low. It was observed directly by AFM that the chaotropic agent guanidinium chloride rapidly breaks the long alpha-Syn fibrils. (c) 2006 Elsevier Ltd. All rights reserved.
KeywordDisassembly Assembly Alpha-synuclein In Situ Atomic Force Microscopy (Afm) Parkinson's Disease
Subject AreaPhysics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000240533000010
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8205
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorTang, L (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Baojia Rd, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Tang, L,Li, HT,Du, HN,et al. Study of the disassembly-assembly process of alpha-synuclein fibrils by in situ atomic force microscopy[J]. MICRON,2006,37(7):675.
APA Tang, L.,Li, HT.,Du, HN.,Zhang, F.,Hu, XF.,...&Tang, L .(2006).Study of the disassembly-assembly process of alpha-synuclein fibrils by in situ atomic force microscopy.MICRON,37(7),675.
MLA Tang, L,et al."Study of the disassembly-assembly process of alpha-synuclein fibrils by in situ atomic force microscopy".MICRON 37.7(2006):675.
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