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Synchrotron microradiography study on acute lung injury of mouse caused by PM2.5 aerosols
Tong, YP(童永彭); Zhang, GL(张桂林); Li, Y(李燕); Tan, MG(谈明光); Wang, W; Chen, JM; Hwu, Y; Fsu, PC; Je, JH; Margaritondo, G; Song, WM; Jiang, RF; Jiang, ZH; Zhang, GL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2006
Source PublicationEUROPEAN JOURNAL OF RADIOLOGY
ISSN0720-048X
Volume58Issue:2Pages:266
AbstractIn order to investigate FeSO4, ZnSO4 (the two of main metal compositions of Shanghai PM2.5 (particle matter with those aerodynamical diameter <2.5 mu m)) effects on acute lung injury, six solutions contained PM2.5 aerosol particles, FeSO4, ZnSO4 and their mixtures were instilled intratracheally into mouse lungs for experiment. By 2 days. after instillation, the live mice were checked in vivo by synchrotron refractive index microradiography. In addition after extracted and examined by dissection, the right lobes of lung were fixed by formalin, then imaged by synchrotron microradiography again. Corresponding parts of those lung tissues were embedded in paraffin for histopathologic study. The synchrotron X-ray microradiographs of live mouse lung showed different lung texture changes after instilled with different toxic solutions. Hemorrhage points in lung were observed more from those mice instilled by FeSO4 contained toxin solutions groups. Bronchial epithelial hyperplasia can be observed in ZnSO4 contained solution-instilled groups from histopathologic analysis. It was found that the acute lung injury of mice caused by solution of PM2.5 + FeSO4 + ZnSO4 was more serious than other toxin solutions. Results suggested that FeSO4 mainly induced hemorrhage and ZnSO4 mainly induced inflammation and bronchiolar epithelial hyperplasia in the early toxicological effects of PM2.5 (C) 2005 Elsevier Ireland Ltd. All rights reserved.
KeywordSynchrotron Microradiography Lung Injury Feso4 Znso4 Pm2.5
Subject AreaEngineering ; Physics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000237615800012
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8209
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorZhang, GL (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Tong, YP,Zhang, GL,Li, Y,et al. Synchrotron microradiography study on acute lung injury of mouse caused by PM2.5 aerosols[J]. EUROPEAN JOURNAL OF RADIOLOGY,2006,58(2):266.
APA Tong, YP.,Zhang, GL.,Li, Y.,Tan, MG.,Wang, W.,...&Zhang, GL .(2006).Synchrotron microradiography study on acute lung injury of mouse caused by PM2.5 aerosols.EUROPEAN JOURNAL OF RADIOLOGY,58(2),266.
MLA Tong, YP,et al."Synchrotron microradiography study on acute lung injury of mouse caused by PM2.5 aerosols".EUROPEAN JOURNAL OF RADIOLOGY 58.2(2006):266.
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