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Synthesis of amino-modified magnetite nanoparticles coated with Hepama-1 and radiolabeled with Re-188 for bio-magnetically targeted radiotherapy
Liang, S; Wang, YX; Zhang(汪勇先), CF; Liu, XQ; Liu, ZF; Xu, RH; Yin, DZ(尹端沚); Liang, S (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China
2006
Source PublicationJOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
ISSN0236-5731
Volume269Issue:1Pages:3
AbstractUltrafine well-dispersed magnetite nanoparticles were directly prepared in aqueous solution using the controlled coprecipitation method. This paper discusses the preparation of novel surface silica modified colloids with a core of single-domain magnetite particles. Amino-silane was covalently coupled to the colloids and activated by glutaraldehyde. The underlying idea is to tailor the silica shell thickness and surface properties such that the colloids became stable spheres with isotropic interactions, whereas an external magnetic field produces weak dipolar attractions and consequently reversible anisotropic structures. Hepama-1, a humanized monoclonal antibody directed against liver cancer, was coated on functional magnetic nanoparticles by the cross-linker glutaraldehyde to prepare immuno-magnetic nanoparticles (IMN). A direct labeling method was adopted to radiolabel IMN with Re-188. The radiolabeling efficiency was about 90% with good in vitro stability. Such nanoparticles might be useful for bio-magnetic radiotherapy.
Subject AreaPhysics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000239298600001
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8213
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorLiang, S (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Liang, S,Wang, YX,Zhang,et al. Synthesis of amino-modified magnetite nanoparticles coated with Hepama-1 and radiolabeled with Re-188 for bio-magnetically targeted radiotherapy[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2006,269(1):3.
APA Liang, S.,Wang, YX.,Zhang.,Liu, XQ.,Liu, ZF.,...&Liang, S .(2006).Synthesis of amino-modified magnetite nanoparticles coated with Hepama-1 and radiolabeled with Re-188 for bio-magnetically targeted radiotherapy.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,269(1),3.
MLA Liang, S,et al."Synthesis of amino-modified magnetite nanoparticles coated with Hepama-1 and radiolabeled with Re-188 for bio-magnetically targeted radiotherapy".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 269.1(2006):3.
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