Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Terahertz time-domain spectroscopy of D-, L-, and DL-penicillamines | |
| Ji, T（吉特）; Zhao, HW（赵红卫）; Zhang, ZY（张增艳）; Ge, M（葛敏）; Wang, WF（王文锋）; Yu, XH（余笑寒）; Xu, HJ（徐洪杰）; Yu, XH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China | |
| 2006 | |
| Source Publication | ACTA PHYSICO-CHIMICA SINICA
 |
| ISSN | 1000-6818 |
| Volume | 22Issue:9Pages:1159 |
| Abstract | Far-infrared absorption spectra of D-, L-, and DL- penicillamines have been measured by terahertz time-domain spectroscopy (THz-TDS) in the frequency range from 0.2 THz to 1.8 THz. The experimental results show large difference among absorption spectra of enantiomers (D- and L- penicillamines) and their racemic compound (DL-penicillamine), which probably originated from the difference of crystal structure and vibration modes of crystal lattice. The study indicates that THz-TDS can be used for discrimination of D-, L-, and DL- penicillamines. The absorption spectra of their mixtures have been fitted by the absorption spectra of D- and L- penicillamines, and we have demonstrated the feasibility of this method to determine quantitatively the mixture ratios of penicillamine enantiomers. These will not only give a new experimental method to distinguish chiral medicine, but also provide a suggestion for further comprehending the interaction of chiral medicine and target biomolecule. |
| Keyword | Thz-tds D- L- And Dl-penicillamines Enantiomers Quantitative Analysis |
| Subject Area | Materials Science ; Physics |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000240704900025 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/8221 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Corresponding Author | Yu, XH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| Recommended Citation GB/T 7714 | Ji, T,Zhao, HW,Zhang, ZY,et al. Terahertz time-domain spectroscopy of D-, L-, and DL-penicillamines[J]. ACTA PHYSICO-CHIMICA SINICA,2006,22(9):1159. |
| APA | Ji, T.,Zhao, HW.,Zhang, ZY.,Ge, M.,Wang, WF.,...&Yu, XH .(2006).Terahertz time-domain spectroscopy of D-, L-, and DL-penicillamines.ACTA PHYSICO-CHIMICA SINICA,22(9),1159. |
| MLA | Ji, T,et al."Terahertz time-domain spectroscopy of D-, L-, and DL-penicillamines".ACTA PHYSICO-CHIMICA SINICA 22.9(2006):1159. |
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