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Terahertz time-domain spectroscopy of D-, L-, and DL-penicillamines
Ji, T(吉特); Zhao, HW(赵红卫); Zhang, ZY(张增艳); Ge, M(葛敏); Wang, WF(王文锋); Yu, XH(余笑寒); Xu, HJ(徐洪杰); Yu, XH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2006
Source PublicationACTA PHYSICO-CHIMICA SINICA
ISSN1000-6818
Volume22Issue:9Pages:1159
AbstractFar-infrared absorption spectra of D-, L-, and DL- penicillamines have been measured by terahertz time-domain spectroscopy (THz-TDS) in the frequency range from 0.2 THz to 1.8 THz. The experimental results show large difference among absorption spectra of enantiomers (D- and L- penicillamines) and their racemic compound (DL-penicillamine), which probably originated from the difference of crystal structure and vibration modes of crystal lattice. The study indicates that THz-TDS can be used for discrimination of D-, L-, and DL- penicillamines. The absorption spectra of their mixtures have been fitted by the absorption spectra of D- and L- penicillamines, and we have demonstrated the feasibility of this method to determine quantitatively the mixture ratios of penicillamine enantiomers. These will not only give a new experimental method to distinguish chiral medicine, but also provide a suggestion for further comprehending the interaction of chiral medicine and target biomolecule.
KeywordThz-tds D- L- And Dl-penicillamines Enantiomers Quantitative Analysis
Subject AreaMaterials Science ; Physics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000240704900025
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8221
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorYu, XH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Ji, T,Zhao, HW,Zhang, ZY,et al. Terahertz time-domain spectroscopy of D-, L-, and DL-penicillamines[J]. ACTA PHYSICO-CHIMICA SINICA,2006,22(9):1159.
APA Ji, T.,Zhao, HW.,Zhang, ZY.,Ge, M.,Wang, WF.,...&Yu, XH .(2006).Terahertz time-domain spectroscopy of D-, L-, and DL-penicillamines.ACTA PHYSICO-CHIMICA SINICA,22(9),1159.
MLA Ji, T,et al."Terahertz time-domain spectroscopy of D-, L-, and DL-penicillamines".ACTA PHYSICO-CHIMICA SINICA 22.9(2006):1159.
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