CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
A strategy for ordered sequencing based on single molecule nanomanipulation
Lu, M; Shi, BC; Li, XL; Lu, JH(吕军鸿); Chen, RS; Hu, J(胡钧); Lu, JH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2006
Source PublicationPROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN1000-3282
Volume33Issue:7Pages:660
AbstractWith the limitations of conventional sequencing technologies, there still remains many gaps in complex genomes including the completed human genome. The closure of gaps as well as the solution of other problems caused by repeat sequences call for the development of novel techniques and strategy. Thus an ordered sequencing strategy is proposed based on the experimental advancements in positioning dissection and isolation of single DNA molecules with AFM nanomanipulation. The preliminary results of computer simulation verify its feasibility and indicate the potentialities in overcoming some intractable problems in current sequencing projects.
KeywordSingle Dna Molecules Atomic Force Microscopy Nanomanipulation Ordered Sequencing Strategy
Subject AreaPhysics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000239288700009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8245
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorLu, JH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Lu, M,Shi, BC,Li, XL,et al. A strategy for ordered sequencing based on single molecule nanomanipulation[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2006,33(7):660.
APA Lu, M.,Shi, BC.,Li, XL.,Lu, JH.,Chen, RS.,...&Lu, JH .(2006).A strategy for ordered sequencing based on single molecule nanomanipulation.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,33(7),660.
MLA Lu, M,et al."A strategy for ordered sequencing based on single molecule nanomanipulation".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 33.7(2006):660.
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