A strategy for ordered sequencing based on single molecule nanomanipulation

CAS OpenIR > 中科院上海应用物理研究所2004-2010年

	A strategy for ordered sequencing based on single molecule nanomanipulation
	Lu, M; Shi, BC; Li, XL; Lu, JH（吕军鸿）; Chen, RS; Hu, J（胡钧）; Lu, JH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
	2006
Source Publication	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN	1000-3282
Volume	33 Issue:7 Pages:660
Abstract	With the limitations of conventional sequencing technologies, there still remains many gaps in complex genomes including the completed human genome. The closure of gaps as well as the solution of other problems caused by repeat sequences call for the development of novel techniques and strategy. Thus an ordered sequencing strategy is proposed based on the experimental advancements in positioning dissection and isolation of single DNA molecules with AFM nanomanipulation. The preliminary results of computer simulation verify its feasibility and indicate the potentialities in overcoming some intractable problems in current sequencing projects.
Keyword	Single Dna Molecules Atomic Force Microscopy Nanomanipulation Ordered Sequencing Strategy
Subject Area	Physics
Indexed By	SCI
Language	英语
Funding Project	应物所项目组
WOS ID	WOS:000239288700009
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sinap.ac.cn/handle/331007/8245
Collection	中科院上海应用物理研究所2004-2010年
Corresponding Author	Lu, JH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation GB/T 7714	Lu, M,Shi, BC,Li, XL,et al. A strategy for ordered sequencing based on single molecule nanomanipulation[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2006,33(7):660.
APA	Lu, M.,Shi, BC.,Li, XL.,Lu, JH.,Chen, RS.,...&Lu, JH .(2006).A strategy for ordered sequencing based on single molecule nanomanipulation.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,33(7),660.
MLA	Lu, M,et al."A strategy for ordered sequencing based on single molecule nanomanipulation".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 33.7(2006):660.

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