Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| A strategy for ordered sequencing based on single molecule nanomanipulation | |
| Lu, M; Shi, BC; Li, XL; Lu, JH（吕军鸿）; Chen, RS; Hu, J（胡钧）; Lu, JH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China | |
| 2006 | |
| Source Publication | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| ISSN | 1000-3282 |
| Volume | 33Issue:7Pages:660 |
| Abstract | With the limitations of conventional sequencing technologies, there still remains many gaps in complex genomes including the completed human genome. The closure of gaps as well as the solution of other problems caused by repeat sequences call for the development of novel techniques and strategy. Thus an ordered sequencing strategy is proposed based on the experimental advancements in positioning dissection and isolation of single DNA molecules with AFM nanomanipulation. The preliminary results of computer simulation verify its feasibility and indicate the potentialities in overcoming some intractable problems in current sequencing projects. |
| Keyword | Single Dna Molecules Atomic Force Microscopy Nanomanipulation Ordered Sequencing Strategy |
| Subject Area | Physics |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 应物所项目组 |
| WOS ID | WOS:000239288700009 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/8245 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Corresponding Author | Lu, JH (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| Recommended Citation GB/T 7714 | Lu, M,Shi, BC,Li, XL,et al. A strategy for ordered sequencing based on single molecule nanomanipulation[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2006,33(7):660. |
| APA | Lu, M.,Shi, BC.,Li, XL.,Lu, JH.,Chen, RS.,...&Lu, JH .(2006).A strategy for ordered sequencing based on single molecule nanomanipulation.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,33(7),660. |
| MLA | Lu, M,et al."A strategy for ordered sequencing based on single molecule nanomanipulation".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 33.7(2006):660. |
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