CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Studies on the photodynamic mechanism of tetrapyrrole compounds by laser flash photolysis
Deng, K; Chen, ZL; Zhou, XP; Wang, WF(王文锋); Yang, XX; Tian, J; Deng, K (reprint author), Donghua Univ, Coll Chem & Biol, Dept Pharm Sci, Shanghai 201620, Peoples R China
2008
Source PublicationCHINESE JOURNAL OF CHEMISTRY
ISSN1001-604X
Volume26Issue:1Pages:202
AbstractPhotodynamic therapy (PDT) is a promising new treatment technique which can potentially destroy unwanted and malignant tissues, such as those of cancer. The photodynamic mechanisms of three tetrapyrrole compounds: Mg-purpurin-18, tetra(meso-chlorophenyl)porphyrin (m-TCPP) and 2,7,12,18-tetramethyl-3,8-di[(1-isobutoxyl)ethyl]- 13,17-bis[3-di(2-chloroethyl)aminopropyl]porphyrin (TDBP) in acetonitrile were investigated by 355 nm laser flash photolysis. It was found that after laser flash photolysis (LFP), the excited states of TDBP and Mg-purpurin-18 could react with O-2 and O-1(2) was produced, which proved that TDBP and Mg-purpurin-18 took effects through type II mechanism in PDT. This suggested that TDBP and Mg-purpurin-18 should be suitable for target tissues containing enough O-2. Mg-purpurin-18 has two extra absorptions at 550 and 700 nm, which means it has broad choices of laser wavelength in PDT. It was also found that m-TCPP could be photoionized when excited with 355 nm laser under N-2-saturated condition. It could also react with O-2 to produce reactive oxygen species such as superoxide and the peroxide anions, but not O-1(2). These were known as the Type I mechanism. So m-TCPP could be used even at low oxygen concentration. or more polar environments with good behavior in PDT. From the above studies on the three different tetrapyrrole compounds it could be concluded that the structure of porphin ring takes a main role in PDT. And there was important impact on the photodynamic mechanism for the functional group directly connecting with porphin ring, while little influence for the functional group indirectly connecting with porphin ring. These will be of great value in the discovery of new PDT drugs.
KeywordFlash Laser Photolysis Photodynamic Therapy Photosensitizer Porphyrin Chlorophyll Derivative
Subject AreaChemistry ; Physics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000252607200039
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8333
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorDeng, K (reprint author), Donghua Univ, Coll Chem & Biol, Dept Pharm Sci, Shanghai 201620, Peoples R China
Recommended Citation
GB/T 7714
Deng, K,Chen, ZL,Zhou, XP,et al. Studies on the photodynamic mechanism of tetrapyrrole compounds by laser flash photolysis[J]. CHINESE JOURNAL OF CHEMISTRY,2008,26(1):202.
APA Deng, K.,Chen, ZL.,Zhou, XP.,Wang, WF.,Yang, XX.,...&Deng, K .(2008).Studies on the photodynamic mechanism of tetrapyrrole compounds by laser flash photolysis.CHINESE JOURNAL OF CHEMISTRY,26(1),202.
MLA Deng, K,et al."Studies on the photodynamic mechanism of tetrapyrrole compounds by laser flash photolysis".CHINESE JOURNAL OF CHEMISTRY 26.1(2008):202.
Files in This Item:
File Name/Size DocType Version Access License
Studies on the photo(259KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Deng, K]'s Articles
[Chen, ZL]'s Articles
[Zhou, XP]'s Articles
Baidu academic
Similar articles in Baidu academic
[Deng, K]'s Articles
[Chen, ZL]'s Articles
[Zhou, XP]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Deng, K]'s Articles
[Chen, ZL]'s Articles
[Zhou, XP]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Studies on the photodynamic mechanism of tetrapyrrole compounds by laser flash photolysis.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.