CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
C_(60)吡咯烷苯氮芥的合成和放射性碘标记
冉铁成; 刘瑞丽; 尹娟娟; 李晴暖; 朱建华; 李文新
2006
Source Publication核技术
Issue5
Abstract为了研究以富勒烯为载体的抗肿瘤药物在生物体内的摄取、分布、代谢情况,利用1,3偶极环加成反应合成了带有抗癌活性药物基团的富勒烯衍生物C60吡咯烷苯氮芥,并用1HNMR、UV、IR等谱学方法对其进行了结构表征,确定了结构,用同位素交换法进行125I标记。结果表明,经过130℃热交换120min后C60吡咯烷苯氮芥的放射性碘标记率可达94%,放化纯度93.7%。
Keyword1 3偶极环加成 C60吡咯烷苯氮芥 放射性碘标记 125i
Indexed ByCNKI
Language中文
Funding Project应物所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8536
Collection中科院上海应用物理研究所2004-2010年
Corresponding Author冉铁成
Recommended Citation
GB/T 7714
冉铁成,刘瑞丽,尹娟娟,等. C_(60)吡咯烷苯氮芥的合成和放射性碘标记[J]. 核技术,2006(5).
APA 冉铁成,刘瑞丽,尹娟娟,李晴暖,朱建华,&李文新.(2006).C_(60)吡咯烷苯氮芥的合成和放射性碘标记.核技术(5).
MLA 冉铁成,et al."C_(60)吡咯烷苯氮芥的合成和放射性碘标记".核技术 .5(2006).
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