CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Radiolabelling of poly(histidine) derivatized biodegradable microspheres with the Re-188 tricarbonyl complex [Re-188(CO)(3)(H2O)(3)](+)
Yu, JF(于俊锋); Hafeli, UO; Xia, JY; Li, SQ; Dong, M; Yin, DZ(尹端沚); Wang, YX(汪勇先); Yu, JF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, POB 800-204, Shanghai 201800, Peoples R China
2005
Source PublicationNUCLEAR MEDICINE COMMUNICATIONS
ISSN0143-3636
Volume26Issue:5Pages:453
AbstractObjectives Many radiopharmaceuticals have been studied as radiation synovectomy agents. In this study, we developed a new potential agent for radiation synovectomy: poly(lactic acid)-histidine (PLA-his) microspheres radiolabelled with [Re-188(CO)(3)(H2O)(3)](+). Methods The reaction conditions for the chelation of [Re-188(CO)(3)(H2O)(3)]+ and the radiolabelling of PLA microspheres were optimized and the stabilities for both steps tested in vitro. Results The chelation efficiency of [Re-188(CO)(3)(H2O)(3)](+) reached 93.12± 1.82% with > 95% radiochemical purity once the colloidal and free Re-188 were removed by a small Sep-Pak column (Plus QMA). More than 90% of radioactivity stayed in the [Re-188(CO)(3)(H(2)0)(3)](+) form over 5 h. The radiolabelling efficiency of PLA-his microspheres with [(188) Re(CO)(3)(H(2)0)(3)](+) was above 92%. After 3 days incubation at 37° C in calf serum, more than 80% of the radioactivity was still bound to the microspheres. Conclusion Such microspheres are potentially useful as a radiation synovectomy agent for the treatment of chronically inflamed arthritic joints. Furthermore, they might be valuable in cancer brachytherapy. © 2005 Lippincott Williams & Wilkins.
KeywordMicrosphere Radiolabelling Re-188 Tricarbonyl Histidine Radiation Synovectomy
Subject AreaPhysics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000228958400010
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8655
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorYu, JF (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, POB 800-204, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Yu, JF,Hafeli, UO,Xia, JY,et al. Radiolabelling of poly(histidine) derivatized biodegradable microspheres with the Re-188 tricarbonyl complex [Re-188(CO)(3)(H2O)(3)](+)[J]. NUCLEAR MEDICINE COMMUNICATIONS,2005,26(5):453.
APA Yu, JF.,Hafeli, UO.,Xia, JY.,Li, SQ.,Dong, M.,...&Yu, JF .(2005).Radiolabelling of poly(histidine) derivatized biodegradable microspheres with the Re-188 tricarbonyl complex [Re-188(CO)(3)(H2O)(3)](+).NUCLEAR MEDICINE COMMUNICATIONS,26(5),453.
MLA Yu, JF,et al."Radiolabelling of poly(histidine) derivatized biodegradable microspheres with the Re-188 tricarbonyl complex [Re-188(CO)(3)(H2O)(3)](+)".NUCLEAR MEDICINE COMMUNICATIONS 26.5(2005):453.
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