CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Size controlling of M-PEIs nanogels via photo-induced Fenton reaction
Xu, DM(徐冬梅); Hong, J(洪军); Sun, HW; Gong, PJ; Dong, L; Sheng, KL(盛康龙); Yao, SD(姚思德); Xu, DM (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
2007
Source PublicationACTA POLYMERICA SINICA
ISSN1000-3304
Issue4Pages:389
AbstractPhoto-induced Fenton reaction was utilized in this paper to control the sizes of polyethylenimine hydrogels (M-PEIs, M, Fe atom) as gene delivery vector. H2O2 and FeCl2 were mixed with PEI pre-polymer in water in a 3-neck quartz flask, and the mixture was stirred vigorously. M-PEIs nanogels dispersed very well in water could be prepared under illumination by use of low-pressure Hg lamps at room temperature. This system was protected from oxygen with N-2. By changing reaction conditions, such as the pH value, reaction time and concentrations of solutes, sizes of M-PEls nanogels could be controlled. It was found that the sizes of M-PEIs decreased with the pH value and the concentrations of FeCl2. The increasing of the initiator (H2O2) concentrations would make the particles more tighten, but might result in crosslinking or degradation of particles. A suitable irradiation time ensured formation of homogeneous nanogel products, but prolonged irradiation would cause degradation of nanogels. After photo crosslinking, the products were purified with membrane filters of 0.45 mu m and treated further by dialysis bags with size exclusion below 10 kDa in order to make them more stable for storage.
KeywordPhotochemistry Polyethyleneimine Nonviral Vector Uv Photo-fenton Reaction
Subject AreaPhysics
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000246040800015
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8665
Collection中科院上海应用物理研究所2004-2010年
Corresponding AuthorXu, DM (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China
Recommended Citation
GB/T 7714
Xu, DM,Hong, J,Sun, HW,et al. Size controlling of M-PEIs nanogels via photo-induced Fenton reaction[J]. ACTA POLYMERICA SINICA,2007(4):389.
APA Xu, DM.,Hong, J.,Sun, HW.,Gong, PJ.,Dong, L.,...&Xu, DM .(2007).Size controlling of M-PEIs nanogels via photo-induced Fenton reaction.ACTA POLYMERICA SINICA(4),389.
MLA Xu, DM,et al."Size controlling of M-PEIs nanogels via photo-induced Fenton reaction".ACTA POLYMERICA SINICA .4(2007):389.
Files in This Item: Download All
File Name/Size DocType Version Access License
Size controlling of (184KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xu, DM(徐冬梅)]'s Articles
[Hong, J(洪军)]'s Articles
[Sun, HW]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xu, DM(徐冬梅)]'s Articles
[Hong, J(洪军)]'s Articles
[Sun, HW]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xu, DM(徐冬梅)]'s Articles
[Hong, J(洪军)]'s Articles
[Sun, HW]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Size controlling of M-PEIs nanogels via photo-induced Fenton reaction.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.