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以光诱导Fenton反应控制M-PEIs纳米凝胶的粒径
徐冬梅; 洪军; 孙汉文; 宫培军; 董黎; 盛康龙; 姚思德
2007-04-15
Source Publication高分子学报
Issue04
Other AbstractPhoto-induced Fenton reaction was utilized in this paper to control the sizes of polyethylenimine hydrogels (M-PEIs,M,Fe atom) as gene delivery vector.H_2O_2 and FeCl_2 were mixed with PEI pre_polymer in water in a 3-neck quartz flask, and the mixture was stirred vigorously.M-PEIs nanogels dispersed very well in water could be prepared under illumination by use of low-pressure Hg lamps at room temperature.This system was protected from oxygen with N_2.By changing reaction conditions,such as the pH value,reaction time and concentrations of solutes,sizes of M-PEIs nanogels could be controlled.It was found that the sizes of M-PEIs decreased with the pH value and the concentrations of FeCl_2.The increasing of the initiator (H_2O_2) concentrations would make the particles more tighten,but might result in crosslinking or degradation of particles.A suitable irradiation time ensured formation of homogeneous nanogel products,but prolonged irradiation would cause degradation of nanogels.After photo crosslinking,the products were purified with membrane filters of 0.45 μm and treated further by dialysis bags with size exclusion below 10 kDa in order to make them more stable for storage.
Indexed ByCNKI
Language中文
Funding Project应物所项目组
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8797
Collection中科院上海应用物理研究所2004-2010年
Corresponding Author徐冬梅
Recommended Citation
GB/T 7714
徐冬梅,洪军,孙汉文,等. 以光诱导Fenton反应控制M-PEIs纳米凝胶的粒径[J]. 高分子学报,2007(04).
APA 徐冬梅.,洪军.,孙汉文.,宫培军.,董黎.,...&姚思德.(2007).以光诱导Fenton反应控制M-PEIs纳米凝胶的粒径.高分子学报(04).
MLA 徐冬梅,et al."以光诱导Fenton反应控制M-PEIs纳米凝胶的粒径".高分子学报 .04(2007).
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