CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Investigation of elemental distribution in human femoral head by PIXE and SRXRF microprobe
Zhang, YX; Wang, YS; Zhang, YP; Zhang, GL(张桂林); Huang, YY; He, W
2007
Conference Name10th International Conference on Nuclear Microprobe Technology and Applications held in Conjunction with the 2nd International Workshop on Proton Beam Writing
Source PublicationNUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
Pages178
Conference DateJUL 09-14, 2006
Conference PlaceSingapore, SINGAPORE
AbstractIn order to study the distribution and possible degenerative processes inducing the loss of inorganic substances in bone and to provide a scientific basis for the prevention and therapy of osteoporosis, proton induced X-ray emission (PIXE) method is used for the determination of elemental concentrations in femoral heads from five autopsies and seven patients with femoral neck fractures. Synchrotron radiation X-ray fluorescence (SRXRF) microprobe analysis technique is used to scan a slice of the femoral head from its periphery to its center, via cartilage, compact and spongy zones. The specimen preparation and experiment procedure are described in detail. The results show that the concentrations of P, Ca, Fe, Cu, Sr in the control group are higher than those in the patient group, but the concentrations of S, K, Zn, Mn are not significantly different. The quantitative results of elemental distribution, such as Ca, P, K, Fe, Zn, Sr and Pb in bone slice tissue including cartilage, substantial compact and substantial spongy, are investigated. The data obtained show that the concentrations of Ca, P, K, (the major elements of bone composition), are obviously low in both spongy and cartilage zones in the patient group, but there are no remarkable differences in the compact zone. Combined with the correlations between P, K, Zn, Sr and Ca, the loss mechanism of minerals and the physiological functions of some metal elements in bone are also discussed. (c) 2007 Elsevier B.V. All rights reserved.
ISSN0168-583X
Indexed BySCI
Funding Project应物所课题组
Language英语
Document Type会议论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8852
Collection中科院上海应用物理研究所2004-2010年
Recommended Citation
GB/T 7714
Zhang, YX,Wang, YS,Zhang, YP,et al. Investigation of elemental distribution in human femoral head by PIXE and SRXRF microprobe[C],2007:178.
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