CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Nano-manipulation of single DNA molecules based on atomic force microscopy
Lu, JH; Li, HK; An, HJ; Wang, GH; Wang, Y(汪颖); Li, MQ(李名乾); Zhang, Y(张益); Li, B(李宾); Hu, J(胡钧)
2005
Conference Name27th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society
Source Publication2005 27TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-7
Pages7478
Conference DateAUG 31-SEP 03, 2005
Conference PlaceShanghai, PEOPLES R CHINA
AbstractNano-manipulation of single atoms and molecules is a critical technique in nanoscience and nanotechnology. This paper will focus on the recent development of the manipulation of single DNA molecules based on atomic force microscopy (AFM) in our laboratory. Precise manipulation has been realized including varied manipulating modes such as "cutting", "pushing", "folding", "kneading", "picking up", "dipping", etc. The cutting accuracy is dominated by the size of the AFM tip, which is usually 10nm or less. Single DNA fragments can be cut and picked up and then amplified by single molecule PCR. Thus positioning isolation and sequencing can be performed.
ISSN1094-687X
ISBN0-7803-8740-6
Indexed BySCI
Funding Project应物所课题组
Language英语
Document Type会议论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/8872
Collection中科院上海应用物理研究所2004-2010年
Recommended Citation
GB/T 7714
Lu, JH,Li, HK,An, HJ,et al. Nano-manipulation of single DNA molecules based on atomic force microscopy[C],2005:7478.
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