Knowledge Management System Of Shanghai Institute of Applied Physics, CAS
| Novel polyethylenimine nanogels as potential gene carriers produced via photochemistry in surfactant-free aqueous solution | |
| Xu, DM（徐冬梅）; Yu, JH; Liu, YB; Sun, HW; Xu, JY; Sheng, KL（盛康龙）; Yao, SD（姚思德）; Xu, YH; Lu, HL | |
| 2006 | |
| Conference Name | 2nd Asian Conference on Nanoscience and Nanotechnology |
| Source Publication | International Journal of Nanoscience, Vol 5, No 6 |
| Pages | 753 |
| Conference Date | NOV 24-27, 2004 |
| Conference Place | Beijing, PEOPLES R CHINA |
| Abstract | Cationic polymer nanogels, positively-charged submicrometer polymeric particles that swell in water, have attracted an increasing research attentions in recent years because of their potential applications as gene carriers. In this paper, we report a novel method to synthesize polyethylenimine (PEI) nanogels with sizes ranging from 80 nm to 200 nm via UV irradiation at room temperature in aqueous solution without adding any kind of surfactants. The morphology of the nanoparticles is determined to be spherical. The nanogels are of high stability, high transfection efficiency, low toxicity and low inummogenicity, as having been confirmed by in vivo tests with mice as an animal model, and by in vitro tests with human lung and liver cancer cells as well. |
| Indexed By | SCI |
| Funding Project | 应物所课题组 |
| Language | 英语 |
| Document Type | 会议论文 |
| Identifier | http://ir.sinap.ac.cn/handle/331007/8875 |
| Collection | 中科院上海应用物理研究所2004-2010年 |
| Recommended Citation GB/T 7714 | Xu, DM,Yu, JH,Liu, YB,et al. Novel polyethylenimine nanogels as potential gene carriers produced via photochemistry in surfactant-free aqueous solution[C],2006:753. |
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