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Biodistribution of co-exposure to multi-walled carbon nanotubes and graphene oxide nanoplatelets radiotracers
Li, Z; Geng, YX; Zhang, XY(张小勇); Qi, W; Fan, QH; Li, Y; Jiao, ZX; Wang, JJ; Tang, YQ; Duan, XJ; Wu, WS
2011
Source PublicationJOURNAL OF NANOPARTICLE RESEARCH
ISSN1388-0764
Volume13Issue:7Pages:2939
AbstractTechnetium-99 ((99m)Tc) was used as an isotope tracer to study the biodistribution of oxidized multi-walled carbon nanotubes (oMWCNTs) and/or graphene oxide nanoplatelets (GONP) after intravenous administration (i.v.). The authors also investigated the histological impact of non-radiolabeled oMWCNT or GONP as they passed through systemic circulation and their excretion pathways in comparison to co-exposure groups of both (oMWCNTs and GONP). Results indicated that oMWCNTs were mainly excreted through feces rather than urine. From the blood, oMWCNTs first entered the stomach, then intestines via chyme, and were finally excreted in feces. GONP also followed this pathway, but could also be excreted through urine when co-exposed with oMWCNTs. In summary, the biodistribution patterns and excretion rates of the nanomaterials in vivo depended on their composition and chemical modifications. A new mechanism is proposed to explain how chemical modification groups affect the behavior of nanomaterials in vivo. The behavior and fate of GONP depended strongly on oMWCNTs in mice in vivo, but the GONP did not affect deeply biodistribution and excretion pattern of oMWCNTs in co-exposure.
Indexed BySCI
Language中文
Funding Project应物所项目组
WOS IDWOS:000291746600027
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9395
Collection中科院上海应用物理研究所2004-2010年
Recommended Citation
GB/T 7714
Li, Z,Geng, YX,Zhang, XY,et al. Biodistribution of co-exposure to multi-walled carbon nanotubes and graphene oxide nanoplatelets radiotracers[J]. JOURNAL OF NANOPARTICLE RESEARCH,2011,13(7):2939.
APA Li, Z.,Geng, YX.,Zhang, XY.,Qi, W.,Fan, QH.,...&Wu, WS.(2011).Biodistribution of co-exposure to multi-walled carbon nanotubes and graphene oxide nanoplatelets radiotracers.JOURNAL OF NANOPARTICLE RESEARCH,13(7),2939.
MLA Li, Z,et al."Biodistribution of co-exposure to multi-walled carbon nanotubes and graphene oxide nanoplatelets radiotracers".JOURNAL OF NANOPARTICLE RESEARCH 13.7(2011):2939.
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