CAS OpenIR  > 中科院上海应用物理研究所2004-2010年
Determining the radial modulus of DNA measured by VPSFM
Chen, YH; Li, XJ; Zhou, XF(周星飞); Sun, JL; Huang, WH; Hu, J(胡钧)
2005
Source PublicationMEASUREMENT TECHNOLOGY AND INTELLIGENT INSTRUMENTS VI
ISSN1013-9826
Volume295-296Pages:83
AbstractMechanical properties of DNA, for example the elastic modulus, are of vital importance for its biological function. Previously, the modulus is mainly obtained by bending, stretching and twisting DNA using various techniques and tools. By applying vibrating mode scanning polarization force microscopy (VPSFM), deformations of DNA under ultra-small indentation forces can be measured and so the radial modulus can be computed. In this paper, modeling of the VPSFM measuring system is presented. The system is modeled as a spring-mass-damper oscillator under various force fields, such as van der Waals force, attractive electrical force and repulsive interactions between the tip and sample. The electrical polarization force is described by using uniformly charged line model and the DNA is considered to be a simple elastic rod. By numerically integrating the equation of tip motion, the contact force and the radial modulus of DNA under different deformation can be calculated. We found that in measuring radial modulus of DNA, the existence of substrate cannot be neglected, especially when the relative large deformation is reached.
Indexed BySCI
Language中文
Funding Project应物所项目组
WOS IDWOS:000231595000014
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9407
Collection中科院上海应用物理研究所2004-2010年
Recommended Citation
GB/T 7714
Chen, YH,Li, XJ,Zhou, XF,et al. Determining the radial modulus of DNA measured by VPSFM[J]. MEASUREMENT TECHNOLOGY AND INTELLIGENT INSTRUMENTS VI,2005,295-296:83.
APA Chen, YH,Li, XJ,Zhou, XF,Sun, JL,Huang, WH,&Hu, J.(2005).Determining the radial modulus of DNA measured by VPSFM.MEASUREMENT TECHNOLOGY AND INTELLIGENT INSTRUMENTS VI,295-296,83.
MLA Chen, YH,et al."Determining the radial modulus of DNA measured by VPSFM".MEASUREMENT TECHNOLOGY AND INTELLIGENT INSTRUMENTS VI 295-296(2005):83.
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