CAS OpenIR  > 中科院上海应用物理研究所2011-2020年
Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion
Lei, Haozhi; Mi, Lijuan(米丽娟); Zhou, Xuejiao; Chen, Jiajia; Hu, Jun(胡钧); Guo, Shouwu; Zhang, Yi(张益)
2011
Source PublicationNANOSCALE
ISSN2040-3364
Volume3Issue:9Pages:3888
AbstractInvestigation into the interactions between graphene oxide (GO) and biomolecules is very important for broad applications of GO in bioassay and bioanalysis. In this work, we describe the interactions between double-stranded DNA (dsDNA) and GO. We demonstrated that dsDNA can bind to GO forming complexes (dsDNA/GO) in the presence of certain salts, which protects dsDNA from being enzymatically digested. On the other hand, we found that a nonionic surfactant, such as triton X-100, can block the formation of dsDNA/GO complexes, so that the enzymatic digestion of dsDNA is restored. These results lead us to believe that the reason for GO protecting dsDNA from enzymatic digestion is the formation of dsDNA/GO complexes hindering the access of DNA enzymes to dsDNA, rather than direct inactivation of the DNA enzymes.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000294472600064
Citation statistics
Cited Times:86[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9454
Collection中科院上海应用物理研究所2011-2020年
Recommended Citation
GB/T 7714
Lei, Haozhi,Mi, Lijuan,Zhou, Xuejiao,et al. Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion[J]. NANOSCALE,2011,3(9):3888.
APA Lei, Haozhi.,Mi, Lijuan.,Zhou, Xuejiao.,Chen, Jiajia.,Hu, Jun.,...&Zhang, Yi.(2011).Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion.NANOSCALE,3(9),3888.
MLA Lei, Haozhi,et al."Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion".NANOSCALE 3.9(2011):3888.
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