CAS OpenIR  > 中科院上海应用物理研究所2011-2019年
Detecting small lung tumors in mouse models by refractive-index microradiology
Chien, Chia-Chi; Zhang, Guilin(张桂林); Hwu, Y.; Liu, Ping(刘平); Yue, Weisheng(岳伟胜); Sun, Jianqi; Li, Yan(李燕); Xue, Hongjie; Xu, Lisa X.; Wang, Chang Hai; Chen, Nanyow; Lu, Chien Hung; Lee, Ting-Kuo; Yang, Yuh-Cheng; Lu, Yen-Ta; Ching, Yu-Tai; Shih, T. F.; Yang, P. C.; Je, J. H.; Margaritondo, G.
2011
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN1618-2642
Volume401Issue:3Pages:827
AbstractRefractive-index (phase-contrast) radiology was able to detect lung tumors less than 1 mm in live mice. Significant micromorphology differences were observed in the microradiographs between normal, inflamed, and lung cancer tissues. This was made possible by the high phase contrast and by the fast image taking that reduces the motion blur. The detection of cancer and inflammation areas by phase contrast microradiology and microtomography was validated by bioluminescence and histopathological analysis. The smallest tumor detected is less than 1 mm(3) with accuracy better than 1 x 10(-3) mm(3). This level of performance is currently suitable for animal studies, while further developments are required for clinical application.
Indexed BySCI
Language英语
Funding Project应物所项目组
WOS IDWOS:000292970200007
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sinap.ac.cn/handle/331007/9483
Collection中科院上海应用物理研究所2011-2019年
Recommended Citation
GB/T 7714
Chien, Chia-Chi,Zhang, Guilin,Hwu, Y.,et al. Detecting small lung tumors in mouse models by refractive-index microradiology[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2011,401(3):827.
APA Chien, Chia-Chi.,Zhang, Guilin.,Hwu, Y..,Liu, Ping.,Yue, Weisheng.,...&Margaritondo, G..(2011).Detecting small lung tumors in mouse models by refractive-index microradiology.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,401(3),827.
MLA Chien, Chia-Chi,et al."Detecting small lung tumors in mouse models by refractive-index microradiology".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 401.3(2011):827.
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